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Fructose-Drinking Water Induced Nonalcoholic Fatty Liver Disease and Ultrastructural Alteration of Hepatocyte Mitochondria in Male Wistar Rat
Joint Authors
Zar Chi, Thent
Haji Suhaimi, Farihah
Mamikutty, Norshalizah
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-26
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Nonalcoholic fatty liver disease (NAFLD) is one of the complications of the metabolic syndrome.
It encompasses a wide range of disease spectrum from simple steatosis to liver cirrhosis.
Structural alteration of hepatic mitochondria might be involved in the pathogenesis of NAFLD.
Aims.
In the present study, we used a newly established model of fructose-induced metabolic syndrome in male Wistar rats in order to investigate the ultrastructural changes in hepatic mitochondria that occur with fructose consumption and their association with NAFLD pathogenesis.
Methods.
The concentration of fructose-drinking water (FDW) used in this study was 20%.
Six male Wistar rats were supplemented with FDW 20% for eight weeks.
Body composition and metabolic parameters were measured before and after 8 weeks of FDW 20%.
Histomorphology of the liver was evaluated and ultrastructural changes of mitochondria were assessed with transmission electron micrograph.
Results.
After 8 weeks of fructose consumption, the animals developed several features of the metabolic syndrome.
Moreover, fructose consumption led to the development of macrovesicular hepatic steatosis and mitochondrial ultrastructural changes, such as increase in mitochondrial size, disruption of the cristae, and reduction of matrix density.
Conclusion.
We conclude that in male Wistar rat 8-week consumption of FDW 20% leads to NAFLD likely via mitochondrial structural alteration.
American Psychological Association (APA)
Mamikutty, Norshalizah& Zar Chi, Thent& Haji Suhaimi, Farihah. 2015. Fructose-Drinking Water Induced Nonalcoholic Fatty Liver Disease and Ultrastructural Alteration of Hepatocyte Mitochondria in Male Wistar Rat. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1057151
Modern Language Association (MLA)
Mamikutty, Norshalizah…[et al.]. Fructose-Drinking Water Induced Nonalcoholic Fatty Liver Disease and Ultrastructural Alteration of Hepatocyte Mitochondria in Male Wistar Rat. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1057151
American Medical Association (AMA)
Mamikutty, Norshalizah& Zar Chi, Thent& Haji Suhaimi, Farihah. Fructose-Drinking Water Induced Nonalcoholic Fatty Liver Disease and Ultrastructural Alteration of Hepatocyte Mitochondria in Male Wistar Rat. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1057151
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057151