Icariin Intervenes in Cardiac Inflammaging through Upregulation of SIRT6 Enzyme Activity and Inhibition of the NF-Kappa B Pathway
Joint Authors
Kalionis, Bill
Chen, Yang
Zhang, Changcheng
Yuan, Ding
Huang, Jianhua
Cai, Waijiao
Fang, Hong
Wu, Junzhen
Xia, Shi-Jin
Sun, Tao
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-20
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The aim of the study was to investigate the effect of icariin (ICA) on cardiac aging through its effects on the SIRT6 enzyme and on the NF-κB pathway.
Investigating the effect of ICA on the enzymatic activity of histone deacetylase SIRT6 revealed a concentration of 10−8 mol/L ICA had a maximum activating effect on histone deacetylase SIRT6 enzymatic activity.
Western analysis showed that ICA upregulated SIRT6 protein expression and downregulated NF-κB (p65) protein expression in animal tissues and cell models.
ICA upregulated the expression of SIRT6 and had an inhibitory effect on NF-κB inflammatory signaling pathways as shown by decreasing mRNA levels of the NF-κB downstream target genes TNF-α, ICAM-1, IL-2, and IL-6.
Those effects were mediated directly or indirectly by SIRT6.
We provided evidence that inflammaging may involve a novel link between the effects of ICA on SIRT6 (a regulator of aging) and NF-κB (a regulator of inflammation).
American Psychological Association (APA)
Chen, Yang& Sun, Tao& Wu, Junzhen& Kalionis, Bill& Zhang, Changcheng& Yuan, Ding…[et al.]. 2015. Icariin Intervenes in Cardiac Inflammaging through Upregulation of SIRT6 Enzyme Activity and Inhibition of the NF-Kappa B Pathway. BioMed Research International،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1057152
Modern Language Association (MLA)
Chen, Yang…[et al.]. Icariin Intervenes in Cardiac Inflammaging through Upregulation of SIRT6 Enzyme Activity and Inhibition of the NF-Kappa B Pathway. BioMed Research International No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1057152
American Medical Association (AMA)
Chen, Yang& Sun, Tao& Wu, Junzhen& Kalionis, Bill& Zhang, Changcheng& Yuan, Ding…[et al.]. Icariin Intervenes in Cardiac Inflammaging through Upregulation of SIRT6 Enzyme Activity and Inhibition of the NF-Kappa B Pathway. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1057152
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057152