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hERG1 Potassium Channels: Novel Biomarkers in Human Solid Cancers
Joint Authors
Lastraioli, Elena
Lottini, Tiziano
Bernini, Marco
Bencini, Lapo
Arcangeli, Annarosa
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Because of their high incidence and mortality solid cancers are a major health problem worldwide.
Although several new biomarkers and potential targets for therapy have been identified through biomolecular research in the last years, the effects on patients’ outcome are still unsatisfactory.
Increasing evidence indicates that hERG1 potassium channels are overexpressed in human primary cancers of different origin and several associations between hERG1 expression and clinicopathological features and/or outcome are emerging.
Aberrant hERG1 expression may be exploited either for early diagnosis (especially in those cancers where it is expressed in the initial steps of tumor progression) or for therapy purposes.
Indeed, hERG1 blockage impairs tumor cell growth both in vitro and in vivo in preclinical mouse model.
hERG1-based tumor therapy in humans, however, encounters the major hindrance of the potential cardiotoxicity that many hERG1 blockers exert.
In this review we focus on recent advances in translational research in some of the most frequent human solid cancers (breast, endometrium, ovary, pancreas, esophagus, stomach, and colorectum) that have been shown to express hERG1 and that are a major health problem.
American Psychological Association (APA)
Lastraioli, Elena& Lottini, Tiziano& Bencini, Lapo& Bernini, Marco& Arcangeli, Annarosa. 2015. hERG1 Potassium Channels: Novel Biomarkers in Human Solid Cancers. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1057155
Modern Language Association (MLA)
Lastraioli, Elena…[et al.]. hERG1 Potassium Channels: Novel Biomarkers in Human Solid Cancers. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1057155
American Medical Association (AMA)
Lastraioli, Elena& Lottini, Tiziano& Bencini, Lapo& Bernini, Marco& Arcangeli, Annarosa. hERG1 Potassium Channels: Novel Biomarkers in Human Solid Cancers. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1057155
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057155