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Probiotics (Bifidobacterium longum) Increase Bone Mass Density and Upregulate Sparc and Bmp-2 Genes in Rats with Bone Loss Resulting from Ovariectomy
Joint Authors
Ng, Min Hwei
Ebrahimi, Mahdi
Parvaneh, Kolsoom
Karimi, Golgis
Sabran, Mohd Redzwan
Abdul-Majeed, Saif
Ahmad, Zuraini
Ibrahim, Zuriati
Jamaluddin, Rosita
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Probiotics are live microorganisms that exert beneficial effects on the host, when administered in adequate amounts.
Mostly, probiotics affect the gastrointestinal (GI) tract of the host and alter the composition of gut microbiota.
Nowadays, the incidence of hip fractures due to osteoporosis is increasing worldwide.
Ovariectomized (OVX) rats have fragile bone due to estrogen deficiency and mimic the menopausal conditions in women.
Therefore, this study aimed to examine the effects of Bifidobacterium longum (B.
longum) on bone mass density (BMD), bone mineral content (BMC), bone remodeling, bone structure, and gene expression in OVX rats.
The rats were randomly assigned into 3 groups (sham, OVX, and the OVX group supplemented with 1 mL of B.
longum 108–109 colony forming units (CFU)/mL).
B.
longum was given once daily for 16 weeks, starting from 2 weeks after the surgery.
The B.
longum supplementation increased (p<0.05) serum osteocalcin (OC) and osteoblasts, bone formation parameters, and decreased serum C-terminal telopeptide (CTX) and osteoclasts, bone resorption parameters.
It also altered the microstructure of the femur.
Consequently, it increased BMD by increasing (p<0.05) the expression of Sparc and Bmp-2 genes.
B.
longum alleviated bone loss in OVX rats and enhanced BMD by decreasing bone resorption and increasing bone formation.
American Psychological Association (APA)
Parvaneh, Kolsoom& Ebrahimi, Mahdi& Sabran, Mohd Redzwan& Karimi, Golgis& Ng, Min Hwei& Abdul-Majeed, Saif…[et al.]. 2015. Probiotics (Bifidobacterium longum) Increase Bone Mass Density and Upregulate Sparc and Bmp-2 Genes in Rats with Bone Loss Resulting from Ovariectomy. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1057156
Modern Language Association (MLA)
Parvaneh, Kolsoom…[et al.]. Probiotics (Bifidobacterium longum) Increase Bone Mass Density and Upregulate Sparc and Bmp-2 Genes in Rats with Bone Loss Resulting from Ovariectomy. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1057156
American Medical Association (AMA)
Parvaneh, Kolsoom& Ebrahimi, Mahdi& Sabran, Mohd Redzwan& Karimi, Golgis& Ng, Min Hwei& Abdul-Majeed, Saif…[et al.]. Probiotics (Bifidobacterium longum) Increase Bone Mass Density and Upregulate Sparc and Bmp-2 Genes in Rats with Bone Loss Resulting from Ovariectomy. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1057156
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057156