Effects of Sevoflurane and Propofol on Organ Blood Flow in Left Ventricular Assist Devices in Pigs
Joint Authors
Delgado-Martos, María Jesús
Morillas-Sendín, Paloma
Barranco, Mónica
del Cañizo, Juan Francisco
Ruíz, Manuel
Quintana-Villamandos, Begoña
Delgado-Baeza, Emilio
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-25
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The aim of this study was to assess the effect of sevoflurane and propofol on organ blood flow in a porcine model with a left ventricular assist device (LVAD).
Ten healthy minipigs were divided into 2 groups (5 per group) according to the anesthetic received (sevoflurane or propofol).
A Biomedicus centrifugal pump was implanted.
Organ blood flow (measured using colored microspheres), markers of tissue injury, and hemodynamic parameters were assessed at baseline (pump off) and after 30 minutes of partial support.
Blood flow was significantly higher in the brain (both frontal lobes), heart (both ventricles), and liver after 30 minutes in the sevoflurane group, although no significant differences were recorded for the lung, kidney, or ileum.
Serum levels of alanine aminotransferase and total bilirubin were significantly higher after 30 minutes in the propofol group, although no significant differences were detected between the groups for other parameters of liver function, kidney function, or lactic acid levels.
The hemodynamic parameters were similar in both groups.
We demonstrated that, compared with propofol, sevoflurane increases blood flow in the brain, liver, and heart after implantation of an LVAD under conditions of partial support.
American Psychological Association (APA)
Morillas-Sendín, Paloma& Delgado-Baeza, Emilio& Delgado-Martos, María Jesús& Barranco, Mónica& del Cañizo, Juan Francisco& Ruíz, Manuel…[et al.]. 2015. Effects of Sevoflurane and Propofol on Organ Blood Flow in Left Ventricular Assist Devices in Pigs. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1057160
Modern Language Association (MLA)
Morillas-Sendín, Paloma…[et al.]. Effects of Sevoflurane and Propofol on Organ Blood Flow in Left Ventricular Assist Devices in Pigs. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1057160
American Medical Association (AMA)
Morillas-Sendín, Paloma& Delgado-Baeza, Emilio& Delgado-Martos, María Jesús& Barranco, Mónica& del Cañizo, Juan Francisco& Ruíz, Manuel…[et al.]. Effects of Sevoflurane and Propofol on Organ Blood Flow in Left Ventricular Assist Devices in Pigs. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1057160
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057160