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Morphological Findings in Trophozoites during Amoebic Abscess Development in Misoprostol-Treated BALBc Mice
Joint Authors
Talamás-Rohana, Patricia
Sánchez-Ramírez, Blanca
González-Horta, Carmen
Ramos-Martínez, Ernesto
Aceves-Cano, Andrés
Gaytán-Ochoa, Rocío
Erosa de la Vega, Gilberto
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-18
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
During amoebic liver abscess (ALA) formation in susceptible animals, immune response is regulated by prostaglandin E2 (PGE2) dependent mechanisms.
The aim of this study was to analyze the effect of misoprostol (MPL), a PGE1 analogue, on ALA formation in BALB/c mice.
Male mice from BALB/c strain were intrahepatically infected with 7.5×105 trophozoites of E.
histolytica strain HM1:IMSS and treated with 10−4 M of MPL daily until sacrifice at 2, 4, and 7 days postinfection (p.i.).
ALA formation was evaluated at 2, 4, and 7 days postinfection; trophozoite morphology was analyzed using immunohistochemistry and image analysis.
Results showed an increase in frequency of ALA formation in infected and MPL-treated mice only at 2 days p.i.
(P=0.03).
A significant diminution in the size of trophozoites was detected in abscesses from mice independently of MPL treatment (from 5.8±1.1 µm at 2 days p.i.
to 2.7±1.9 µm at 7 days p.i.) compared with trophozoites dimensions observed in susceptible hamsters (9.6±2.7 µm) (P<0.01).
These results suggest that MPL treatment may modify the adequate control of inflammatory process to allow the persistence of trophozoites in the liver; however, natural resistance mechanisms cannot be discarded.
American Psychological Association (APA)
Aceves-Cano, Andrés& Gaytán-Ochoa, Rocío& Ramos-Martínez, Ernesto& Erosa de la Vega, Gilberto& González-Horta, Carmen& Talamás-Rohana, Patricia…[et al.]. 2015. Morphological Findings in Trophozoites during Amoebic Abscess Development in Misoprostol-Treated BALBc Mice. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1057161
Modern Language Association (MLA)
Aceves-Cano, Andrés…[et al.]. Morphological Findings in Trophozoites during Amoebic Abscess Development in Misoprostol-Treated BALBc Mice. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1057161
American Medical Association (AMA)
Aceves-Cano, Andrés& Gaytán-Ochoa, Rocío& Ramos-Martínez, Ernesto& Erosa de la Vega, Gilberto& González-Horta, Carmen& Talamás-Rohana, Patricia…[et al.]. Morphological Findings in Trophozoites during Amoebic Abscess Development in Misoprostol-Treated BALBc Mice. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1057161
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057161