The Roles of Hedgehog Signaling in Upper Lip Formation
Author
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-03
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Craniofacial development consists of a highly complex sequence of the orchestrated growth and fusion of facial processes.
It is also known that craniofacial abnormalities can be detected in 1/3 of all patients with congenital diseases.
Within the various craniofacial abnormalities, orofacial clefting is one of the most common phenotypic outcomes associated with retarded facial growth or fusion.
Cleft lip is one of the representative and frequently encountered conditions in the spectrum of orofacial clefting.
Despite various mechanisms or signaling pathways that have been proposed to be the cause of cleft lip, a detailed mechanism that bridges individual signaling pathways to the cleft lip is still elusive.
Shh signaling is indispensable for normal embryonic development, and disruption can result in a wide spectrum of craniofacial disorders, including cleft lip.
This review focuses on the current knowledge about the mechanisms of facial development and the etiology of cleft lip that are related to Shh signaling.
American Psychological Association (APA)
Kurosaka, Hiroshi. 2015. The Roles of Hedgehog Signaling in Upper Lip Formation. BioMed Research International،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1057163
Modern Language Association (MLA)
Kurosaka, Hiroshi. The Roles of Hedgehog Signaling in Upper Lip Formation. BioMed Research International No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1057163
American Medical Association (AMA)
Kurosaka, Hiroshi. The Roles of Hedgehog Signaling in Upper Lip Formation. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1057163
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057163