Effects of the Chinese Herbal Formulation (Liu Wei Di Huang Wan) on the Pharmacokinetics of Isoflavones in Postmenopausal Women
Joint Authors
Sangdee, Chaichan
Limopasmanee, Wirin
Chansakaow, Sunee
Rojanasthien, Noppamas
Teekachunhatean, Supanimit
Manorot, Maleeya
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
A combination of soy isoflavones and Liu Wei Di Huang Wan (LWDHW) is potentially effective for postmenopausal women with intolerable vasomotor episodes who are not suitable candidates for hormonal therapy.
The objective of this open-label, three-phase, crossover study was to determine the influence of both single and multiple oral doses of LWDHW on isoflavone pharmacokinetics in healthy postmenopausal women.
Eleven subjects were assigned to receive the following regimens in a fixed sequence with washout periods of at least one week: Phase A, a single oral dose of soy milk; Phase B, a single oral dose of soy milk coadministered with LWDHW; and Phase C, multiple oral doses of LWDHW for 14 days followed by a single oral dose of soy milk.
Blood samples were collected and mixed with β-glucuronidase/sulfatase to hydrolyze isoflavone conjugates to their respective aglycones (i.e., daidzein and genistein) and were determined using high performance liquid chromatography.
The pharmacokinetic parameters analyzed were maximal plasma concentration Cmax, time to reach peak concentration Tmax, area under the plasma concentration-time curve (AUC), and half-life (t1/2).
The results found no statistically significant differences in pharmacokinetic parameters of daidzein and genistein among the three regimens.
American Psychological Association (APA)
Limopasmanee, Wirin& Chansakaow, Sunee& Rojanasthien, Noppamas& Manorot, Maleeya& Sangdee, Chaichan& Teekachunhatean, Supanimit. 2015. Effects of the Chinese Herbal Formulation (Liu Wei Di Huang Wan) on the Pharmacokinetics of Isoflavones in Postmenopausal Women. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1057172
Modern Language Association (MLA)
Limopasmanee, Wirin…[et al.]. Effects of the Chinese Herbal Formulation (Liu Wei Di Huang Wan) on the Pharmacokinetics of Isoflavones in Postmenopausal Women. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1057172
American Medical Association (AMA)
Limopasmanee, Wirin& Chansakaow, Sunee& Rojanasthien, Noppamas& Manorot, Maleeya& Sangdee, Chaichan& Teekachunhatean, Supanimit. Effects of the Chinese Herbal Formulation (Liu Wei Di Huang Wan) on the Pharmacokinetics of Isoflavones in Postmenopausal Women. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1057172
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057172