Alterations of Dendritic Cells in Sepsis: Featured Role in Immunoparalysis
Joint Authors
Liang, Huaping
Jin, He
Fan, Xia
Liu, Zheng
Yan, Jun
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-02
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Sepsis, the leading cause of mortality in intensive care unit, is characterized by hyperinflammatory response in the early stage and followed by a period of immunosuppression.
This immune disorder is believed to be the potent factor that is tightly associated with high mortality in sepsis.
Dendritic cells (DCs) serve as professional antigen-presenting cells that play a vital role in immune response by activating T lymphocytes.
During the progression of sepsis, DCs have been reported to take part in the aberrant immune response and be necessary for survival.
Therefore, a better understanding of the DCs pathology will be undoubtedly beneficial for resolving the problems occurring in sepsis.
This review discusses effects of sepsis on DCs number and function, including surface molecules expression, cytokines secretion, and T cell activation, and the underlying mechanism as well as some potential therapeutic strategies.
American Psychological Association (APA)
Fan, Xia& Liu, Zheng& Jin, He& Yan, Jun& Liang, Huaping. 2015. Alterations of Dendritic Cells in Sepsis: Featured Role in Immunoparalysis. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1057177
Modern Language Association (MLA)
Fan, Xia…[et al.]. Alterations of Dendritic Cells in Sepsis: Featured Role in Immunoparalysis. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1057177
American Medical Association (AMA)
Fan, Xia& Liu, Zheng& Jin, He& Yan, Jun& Liang, Huaping. Alterations of Dendritic Cells in Sepsis: Featured Role in Immunoparalysis. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1057177
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057177