D-Aspartate Modulates Nociceptive-Specific Neuron Activity and Pain Threshold in Inflammatory and Neuropathic Pain Condition in Mice
Joint Authors
Boccella, Serena
Vacca, Valentina
Errico, Francesco
Marinelli, Sara
Squillace, Marta
Guida, Francesca
Di Maio, Anna
Vitucci, Daniela
Palazzo, Enza
De Novellis, Vito
Maione, Sabatino
Pavone, Flaminia
Usiello, Alessandro
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-05
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
D-Aspartate (D-Asp) is a free D-amino acid found in the mammalian brain with a temporal-dependent concentration based on the postnatal expression of its metabolizing enzyme D-aspartate oxidase (DDO).
D-Asp acts as an agonist on NMDA receptors (NMDARs).
Accordingly, high levels of D-Asp in knockout mice for Ddo gene (Ddo −/−) or in mice treated with D-Asp increase NMDAR-dependent processes.
We have here evaluated in Ddo −/− mice the effect of high levels of free D-Asp on the long-term plastic changes along the nociceptive pathway occurring in chronic and acute pain condition.
We found that Ddo −/− mice show an increased evoked activity of the nociceptive specific (NS) neurons of the dorsal horn of the spinal cord (L4–L6) and a significant decrease of mechanical and thermal thresholds, as compared to control mice.
Moreover, Ddo gene deletion exacerbated the nocifensive responses in the formalin test and slightly reduced pain thresholds in neuropathic mice up to 7 days after chronic constriction injury.
These findings suggest that the NMDAR agonist, D-Asp, may play a role in the regulation of NS neuron electrophysiological activity and behavioral responses in physiological and pathological pain conditions.
American Psychological Association (APA)
Boccella, Serena& Vacca, Valentina& Errico, Francesco& Marinelli, Sara& Squillace, Marta& Guida, Francesca…[et al.]. 2015. D-Aspartate Modulates Nociceptive-Specific Neuron Activity and Pain Threshold in Inflammatory and Neuropathic Pain Condition in Mice. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1057186
Modern Language Association (MLA)
Boccella, Serena…[et al.]. D-Aspartate Modulates Nociceptive-Specific Neuron Activity and Pain Threshold in Inflammatory and Neuropathic Pain Condition in Mice. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1057186
American Medical Association (AMA)
Boccella, Serena& Vacca, Valentina& Errico, Francesco& Marinelli, Sara& Squillace, Marta& Guida, Francesca…[et al.]. D-Aspartate Modulates Nociceptive-Specific Neuron Activity and Pain Threshold in Inflammatory and Neuropathic Pain Condition in Mice. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1057186
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057186