The Differential Effects of a Selective Kappa-Opioid Receptor Agonist, U50488, in Guinea Pig Heart Tissues
Joint Authors
Hung, Chi-Feng
Li, Hsin-Ju
Chang, Hsun-Hao
Lee, Gon-Ann
Su, Ming Jai
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-01
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The differential effects of a selective kappa- (κ-) opioid receptor agonist, U50488, were elucidated by monitoring the contraction of isolated guinea pig atrial and ventricular muscles.
In electrically driven left atria, U50488 in nanomolar concentration range decreased the contractile force.
Norbinaltorphimine (norBNI), a selective κ-receptor antagonist, and pertussis toxin (PTX) abolished the negative inotropic effect of U50488.
In contrast, the inhibitory effect was not affected by the pretreatment of atropine or propranolol.
Even though U50488 exerted a negative inotropic effect in the left atrium, it did not affect the contractile force of the right atrium and ventricles paced at 2 Hz.
Similarly, the beating rate of the spontaneously beating right atrium was also unaffected by U50488.
These results indicate that the activation of κ-opioid receptors can only produce negative inotropic effect in left atria via activation of PTX-sensitive G protein in guinea pigs.
The absence of negative inotropic effects in right atria and ventricles suggests that there may be a greater distribution of functional κ-opioid receptors in guinea pig left atria than in right atria and ventricles, and the distribution of the receptors may be species-specific.
American Psychological Association (APA)
Hung, Chi-Feng& Li, Hsin-Ju& Chang, Hsun-Hao& Lee, Gon-Ann& Su, Ming Jai. 2015. The Differential Effects of a Selective Kappa-Opioid Receptor Agonist, U50488, in Guinea Pig Heart Tissues. BioMed Research International،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1057187
Modern Language Association (MLA)
Hung, Chi-Feng…[et al.]. The Differential Effects of a Selective Kappa-Opioid Receptor Agonist, U50488, in Guinea Pig Heart Tissues. BioMed Research International No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1057187
American Medical Association (AMA)
Hung, Chi-Feng& Li, Hsin-Ju& Chang, Hsun-Hao& Lee, Gon-Ann& Su, Ming Jai. The Differential Effects of a Selective Kappa-Opioid Receptor Agonist, U50488, in Guinea Pig Heart Tissues. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1057187
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057187