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The Impact of Thrombocytopenia on Outcome in Patients with Acute Coronary Syndromes: A Single Center Retrospective Study
Joint Authors
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-04
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
In acute coronary syndromes (ACS), treated by combined antithrombotic therapy and percutaneous coronary interventions (PCI), thrombocytopenia may occur.
Our aim was to evaluate predictors and the impact of thrombocytopenia on mortality in high-risk ACS patients.
Methods.
We retrospectively evaluated high-risk ACS patients.
Thrombocytopenia was defined as platelet count <140.000/mL or a drop in platelet count of >50% during in-hospital stay.
We compared demographic, laboratory, clinical, and mortality data between nonthrombocytopenic and thrombocytopenic ACS patients and evaluated independent predictors of thrombocytopenia.
Results.
In 371 ACS patients, thrombocytopenia was observed in 21.3%.
Thrombocytopenic patients were significantly older and, less likely treated by PCIs (72.1% versus 89.7%, p<0.001) and combined antithrombotic therapy, with increased incidence of in-hospital complications and the use of additional treatments, but with increased mortality at 30 days (27.8% versus 10.2%, p<0.001) and 6 months (35.4% versus 13.6%, p<0.001) when compared to nonthrombocytopenic patients.
The use of antibiotics, transfusions, insertion of intra-aortic balloon pump (IABP), and prior stroke independently predicted thrombocytopenia.
Conclusions.
Thrombocytopenia, observed in about 20% of high-risk ACS patients, was associated significantly with in-hospital complications and mortality.
Predictors of thrombocytopenia were the use of antibiotics, transfusions, insertion of IABP, and prior stroke.
American Psychological Association (APA)
Sinkovič, Andreja& Majal, Maja. 2015. The Impact of Thrombocytopenia on Outcome in Patients with Acute Coronary Syndromes: A Single Center Retrospective Study. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1057189
Modern Language Association (MLA)
Sinkovič, Andreja& Majal, Maja. The Impact of Thrombocytopenia on Outcome in Patients with Acute Coronary Syndromes: A Single Center Retrospective Study. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1057189
American Medical Association (AMA)
Sinkovič, Andreja& Majal, Maja. The Impact of Thrombocytopenia on Outcome in Patients with Acute Coronary Syndromes: A Single Center Retrospective Study. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1057189
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057189