Patients with Intolerance Reactions to Total Knee Replacement: Combined Assessment of Allergy Diagnostics, Periprosthetic Histology, and Peri-implant Cytokine Expression Pattern
Joint Authors
Flaig, Michael J.
Thomas, Peter
Summer, Burkhard
von der Helm, Christine
Schopf, Christoph
Mazoochian, Farhad
Frommelt, Lars
Gollwitzer, Hans
Schneider, Josef
Krenn, Veit
Thomas, Benjamin
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-19
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
We performed a combined approach to identify suspected allergy to knee arthroplasty (TKR): patch test (PT), lymphocyte transformation test (LTT), histopathology (overall grading; T- and B-lymphocytes, macrophages, and neutrophils), and semiquantitative Real-time-PCR-based periprosthetic inflammatory mediator analysis (IFNγ, TNFα, IL1-β, IL-2, IL-6, IL-8, IL-10, IL17, and TGFβ).
We analyzed 25 TKR patients with yet unexplained complications like pain, effusion, and reduced range of motion.
They consisted of 20 patients with proven metal sensitization (11 with PT reactions; 9 with only LTT reactivity).
Control specimens were from 5 complicated TKR patients without metal sensitization, 12 OA patients before arthroplasty, and 8 PT patients without arthroplasty.
Lymphocytic infiltrates were seen and fibrotic (Type IV membrane) tissue response was most frequent in the metal sensitive patients, for example, in 81% of the PT positive patients.
The latter also had marked periprosthetic IFNγ expression.
8/9 patients with revision surgery using Ti-coated/oxinium based implants reported symptom relief.
Our findings demonstrate that combining allergy diagnostics with histopathology and periprosthetic cytokine assessment could allow us to design better diagnostic strategies.
American Psychological Association (APA)
Thomas, Peter& von der Helm, Christine& Schopf, Christoph& Mazoochian, Farhad& Frommelt, Lars& Gollwitzer, Hans…[et al.]. 2015. Patients with Intolerance Reactions to Total Knee Replacement: Combined Assessment of Allergy Diagnostics, Periprosthetic Histology, and Peri-implant Cytokine Expression Pattern. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1057200
Modern Language Association (MLA)
Thomas, Peter…[et al.]. Patients with Intolerance Reactions to Total Knee Replacement: Combined Assessment of Allergy Diagnostics, Periprosthetic Histology, and Peri-implant Cytokine Expression Pattern. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1057200
American Medical Association (AMA)
Thomas, Peter& von der Helm, Christine& Schopf, Christoph& Mazoochian, Farhad& Frommelt, Lars& Gollwitzer, Hans…[et al.]. Patients with Intolerance Reactions to Total Knee Replacement: Combined Assessment of Allergy Diagnostics, Periprosthetic Histology, and Peri-implant Cytokine Expression Pattern. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1057200
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057200