Screening Active Compounds from Garcinia Species Native to China Reveals Novel Compounds Targeting the STATJAK Signaling Pathway
Joint Authors
Xu, Hong-Xi
Xu, Linfeng
Lao, Yuanzhi
Zhao, Yanhui
Qin, Jian
Fu, Wenwei
Zhang, Yingjia
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Natural compounds from medicinal plants are important resources for drug development.
In a panel of human tumor cells, we screened a library of the natural products from Garcinia species which have anticancer potential to identify new potential therapeutic leads and discovered that caged xanthones were highly effective at suppressing multiple cancer cell lines.
Their anticancer activities mainly depended on apoptosis pathways.
For compounds in sensitive cancer line, their mechanisms of mode of action were evaluated.
33-Hydroxyepigambogic acid and 35-hydroxyepigambogic acid exhibited about 1 μM IC50 values against JAK2/JAK3 kinases and less than 1 μM IC50 values against NCI-H1650 cell which autocrined IL-6.
Thus these two compounds provided a new antitumor molecular scaffold.
Our report describes 33-hydroxyepigambogic acid and 35-hydroxyepigambogic acid that inhibited NCI-H1650 cell growth by suppressing constitutive STAT3 activation via direct inhibition of JAK kinase activity.
American Psychological Association (APA)
Xu, Linfeng& Lao, Yuanzhi& Zhao, Yanhui& Qin, Jian& Fu, Wenwei& Zhang, Yingjia…[et al.]. 2015. Screening Active Compounds from Garcinia Species Native to China Reveals Novel Compounds Targeting the STATJAK Signaling Pathway. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1057203
Modern Language Association (MLA)
Xu, Linfeng…[et al.]. Screening Active Compounds from Garcinia Species Native to China Reveals Novel Compounds Targeting the STATJAK Signaling Pathway. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1057203
American Medical Association (AMA)
Xu, Linfeng& Lao, Yuanzhi& Zhao, Yanhui& Qin, Jian& Fu, Wenwei& Zhang, Yingjia…[et al.]. Screening Active Compounds from Garcinia Species Native to China Reveals Novel Compounds Targeting the STATJAK Signaling Pathway. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1057203
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057203