Large-Vessel Vasculitis: Interobserver Agreement and Diagnostic Accuracy of 18F-FDG-PETCT
Joint Authors
Smulders, Yvo M.
Slart, Riemer H. J. A.
Voskuyl, Alexandre E.
van der Laken, Conny J.
Lensen, K. D. F.
Comans, E. F. I.
Brouwer, E.
Zwijnenburg, A. T.
Pereira Arias-Bouda, L. M.
Glaudemans, Andor W. J. M.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Introduction.
18F-FDG-PET visualises inflammation.
Both atherosclerosis and giant cell arteritis cause vascular inflammation, but distinguishing the two may be difficult.
The goal of this study was to assess interobserver agreement and diagnostic accuracy of 18F-FDG-PET for the detection of large artery involvement in giant cell arteritis (GCA).
Methods.
31 18F-FDG-PET/CT scans were selected from 2 databases.
Four observers assessed vascular wall 18F-FDG uptake, initially without and subsequently with predefined observer criteria (i.e., vascular wall 18F-FDG uptake compared to liver or femoral artery 18F-FDG uptake).
External validation was performed by two additional observers.
Sensitivity and specificity of 18F-FDG-PET were determined by comparing scan results to a consensus diagnosis.
Results.
The highest interobserver agreement (kappa: 0.96 in initial study and 0.79 in external validation) was observed when vascular wall 18F-FDG uptake higher than liver uptake was used as a diagnostic criterion, although agreement was also good without predefined criteria (kappa: 0.68 and 0.85).
Sensitivity and specificity were comparable for these methods.
The criterion of vascular wall 18F-FDG uptake equal to liver 18F-FDG uptake had low specificity.
Conclusion.
Standardization of image assessment for vascular wall 18F-FDG uptake promotes observer agreement, enables comparative studies, and does not appear to result in loss of diagnostic accuracy compared to nonstandardized assessment.
American Psychological Association (APA)
Lensen, K. D. F.& Comans, E. F. I.& Voskuyl, Alexandre E.& van der Laken, Conny J.& Brouwer, E.& Zwijnenburg, A. T.…[et al.]. 2015. Large-Vessel Vasculitis: Interobserver Agreement and Diagnostic Accuracy of 18F-FDG-PETCT. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1057213
Modern Language Association (MLA)
Lensen, K. D. F.…[et al.]. Large-Vessel Vasculitis: Interobserver Agreement and Diagnostic Accuracy of 18F-FDG-PETCT. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1057213
American Medical Association (AMA)
Lensen, K. D. F.& Comans, E. F. I.& Voskuyl, Alexandre E.& van der Laken, Conny J.& Brouwer, E.& Zwijnenburg, A. T.…[et al.]. Large-Vessel Vasculitis: Interobserver Agreement and Diagnostic Accuracy of 18F-FDG-PETCT. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1057213
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057213