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Effects of Two Fullerene Derivatives on Monocytes and Macrophages
Joint Authors
Pacor, Sabrina
Grillo, Alberto
Đorđević, Luka
Zorzet, Sonia
Lucafò, Marianna
Da Ros, Tatiana
Prato, Maurizio
Sava, Gianni
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-19
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Two fullerene derivatives (fullerenes 1 and 2), bearing a hydrophilic chain on the pyrrolidinic nitrogen, were developed with the aim to deliver anticancer agents to solid tumors.
These two compounds showed a significantly different behaviour on human neoplastic cell lines in vitro in respect to healthy leukocytes.
In particular, the pyrrolidinium ring on the fullerene carbon cage brings to a more active compound.
In the present work, we describe the effects of these fullerenes on primary cultures of human monocytes and macrophages, two kinds of immune cells representing the first line of defence in the immune response to foreign materials.
These compounds are not recognized by circulating monocytes while they get into macrophages.
The evaluation of the pronecrotic or proapoptotic effects, analysed by means of analysis of the purinergic receptor P2X7 activation and of ROS scavenging activity, has allowed us to show that fullerene 2, but not its analogue fullerene 1, displays toxicity, even though at concentrations higher than those shown to be active on neoplastic cells.
American Psychological Association (APA)
Pacor, Sabrina& Grillo, Alberto& Đorđević, Luka& Zorzet, Sonia& Lucafò, Marianna& Da Ros, Tatiana…[et al.]. 2015. Effects of Two Fullerene Derivatives on Monocytes and Macrophages. BioMed Research International،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1057220
Modern Language Association (MLA)
Pacor, Sabrina…[et al.]. Effects of Two Fullerene Derivatives on Monocytes and Macrophages. BioMed Research International No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1057220
American Medical Association (AMA)
Pacor, Sabrina& Grillo, Alberto& Đorđević, Luka& Zorzet, Sonia& Lucafò, Marianna& Da Ros, Tatiana…[et al.]. Effects of Two Fullerene Derivatives on Monocytes and Macrophages. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1057220
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057220