Effects of Acute Lithium Treatment on Brain Levels of Inflammatory Mediators in Poststroke Rats
Joint Authors
Nassar, Ahmad
Kaplanski, Jacob
Zlotnik, Alexander
Sharon-Granit, Yael
Azab, Abed N.
Boyko, Matthew
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Stroke is a leading cause of mortality and morbidity worldwide.
Few therapeutic options with proven efficacy are available for the treatment of this disabling disease.
Lithium is the gold standard treatment for bipolar disorder.
Moreover, lithium has been shown to exhibit neuroprotective effects and therapeutic efficacy as a treatment of other neurological disorders.
This study was undertaken to examine the effects of lithium on brain inflammatory mediators levels, fever, and mortality in postischemic stroke rats.
Ischemic stroke was induced by occlusion of the mid cerebral artery (MCAO).
Pretreatment with a single dose of lithium at 2 hours before MCAO induction significantly reduced the elevation in interleukin- (IL-) 6 and prostaglandin E2 levels in brain of post-MCAO rats, as compared to vehicle-treated animals.
On the other hand, lithium did not affect the elevation in IL-1α, IL-10, IL-12, and tumor necrosis factor-α levels in brain of post-MCAO rats.
Moreover, pretreatment with lithium did not alter post-MCAO fever and mortality.
These results suggest that acute pretreatment with a single dose of lithium did not markedly affect post-MCAO morbidity and mortality in rats.
American Psychological Association (APA)
Boyko, Matthew& Nassar, Ahmad& Kaplanski, Jacob& Zlotnik, Alexander& Sharon-Granit, Yael& Azab, Abed N.. 2015. Effects of Acute Lithium Treatment on Brain Levels of Inflammatory Mediators in Poststroke Rats. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1057224
Modern Language Association (MLA)
Boyko, Matthew…[et al.]. Effects of Acute Lithium Treatment on Brain Levels of Inflammatory Mediators in Poststroke Rats. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1057224
American Medical Association (AMA)
Boyko, Matthew& Nassar, Ahmad& Kaplanski, Jacob& Zlotnik, Alexander& Sharon-Granit, Yael& Azab, Abed N.. Effects of Acute Lithium Treatment on Brain Levels of Inflammatory Mediators in Poststroke Rats. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1057224
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057224