The Gastrointestinal Irritation of Polygala Saponins and Its Potential Mechanism In Vitro and In Vivo
Joint Authors
Wen, Li
Xia, Nan
Tang, PeiPei
Hong, Yi
Wang, ZiZhen
Liu, YaJie
Liu, YanJu
Liu, JianJun
Li, XiangQiong
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-01
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Processing alters the pharmacological activity and reduces the gastrointestinal toxicity of the polygalae.
To investigate the effect of processing, different glycosyl substituent products were tested.
Hypnotic and subhypnotic doses of pentobarbital-induced sleep tests on mice were used to evaluate the sedative activity of polygala saponins with different glycosyl substituents; isolated gut motility experiment was employed to study excitatory effects of different polygala saponins; the gastrointestinal irritation effects of different polygala saponins were compared by measuring the levels of gastric PGE2 and intestinal TNF-α on mice.
When compared with control, Onjisaponin B (OJB) and tenuifolin (TEN), but not senegenin (SNG), significantly increased the number of sleeping mice and prolonged the sleeping time ( P < 0.05 ); 80, 40, and 20 mg/L of OJB and 80 mg/L of TEN, but not SNG, obviously changed the amplitude and frequency of isolated jejunum ( P < 0.05 ); all the three compounds significantly decreased the level of gastric PGE2 but had no obvious influences on the reduction of intestinal TNF-α level.
For sedative and hypnotic effects, OJB > TEN > SNG; for the protection form gastrointestinal irritation and damages, OJB > TEN > SNG.
Therefore, in processing Polygala, glycosyl breaking may be related to the decline of pharmacological activity and gastrointestinal toxicity of polygala saponins.
American Psychological Association (APA)
Wen, Li& Xia, Nan& Tang, PeiPei& Hong, Yi& Wang, ZiZhen& Liu, YaJie…[et al.]. 2015. The Gastrointestinal Irritation of Polygala Saponins and Its Potential Mechanism In Vitro and In Vivo. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1057236
Modern Language Association (MLA)
Wen, Li…[et al.]. The Gastrointestinal Irritation of Polygala Saponins and Its Potential Mechanism In Vitro and In Vivo. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1057236
American Medical Association (AMA)
Wen, Li& Xia, Nan& Tang, PeiPei& Hong, Yi& Wang, ZiZhen& Liu, YaJie…[et al.]. The Gastrointestinal Irritation of Polygala Saponins and Its Potential Mechanism In Vitro and In Vivo. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1057236
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057236