Impaired Circulating Angiogenic Cells Mobilization and Metalloproteinase-9 Activity after Dynamic Exercise in Early Metabolic Syndrome
Joint Authors
Nobrega, Antonio C. L.
Rocha, Natalia G.
Sales, Allan R. K.
Penedo, Leticia A.
Pereira, Felipe S.
Silva, Mayra S.
Miranda, Renan L.
Silva, Jemima F. R.
Santos, Aline A.
Silva, Bruno Moreira
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Increased levels of adhesion molecules or metalloproteinases (MMPs) may indicate endothelial dysfunction.
Exercise mobilizes circulating angiogenic cells (CACs) from bone marrow in healthy subjects, improving vascular function.
However, it is unclear whether this mechanism is preserved in the early stages of metabolic syndrome (early MetS).
We aimed to evaluate the acute effects of exercise on adhesion molecules, angiogenic factors, MMPs, and CACs in early MetS.
Fifteen subjects with early MetS and nine healthy controls underwent an exercise session and a nonexercise session, randomly.
Adhesion molecules, angiogenic factors, CACs, and MMPs were evaluated before and after exercise or nonexercise sessions.
At baseline, levels of sE-selectin, sICAM-1, and MMP-9 were higher in early MetS than in controls (P≤0.03).
After exercise, sE-selectin, sICAM-1, and MMP-9 levels were still higher in early MetS (P<0.05).
Subjects with early MetS presented less CACs (P=0.02) and higher MMP-9 activity (P≤0.04), while healthy controls presented higher MMP-2 activity after exercise.
There was no difference between moments in nonexercise session (P>0.05).
In conclusion, subjects with early MetS already presented impaired endothelial function at rest along with a decrease in CACs and an increase in MMP-9 activity in response to exercise.
American Psychological Association (APA)
Rocha, Natalia G.& Sales, Allan R. K.& Penedo, Leticia A.& Pereira, Felipe S.& Silva, Mayra S.& Miranda, Renan L.…[et al.]. 2015. Impaired Circulating Angiogenic Cells Mobilization and Metalloproteinase-9 Activity after Dynamic Exercise in Early Metabolic Syndrome. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1057246
Modern Language Association (MLA)
Rocha, Natalia G.…[et al.]. Impaired Circulating Angiogenic Cells Mobilization and Metalloproteinase-9 Activity after Dynamic Exercise in Early Metabolic Syndrome. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1057246
American Medical Association (AMA)
Rocha, Natalia G.& Sales, Allan R. K.& Penedo, Leticia A.& Pereira, Felipe S.& Silva, Mayra S.& Miranda, Renan L.…[et al.]. Impaired Circulating Angiogenic Cells Mobilization and Metalloproteinase-9 Activity after Dynamic Exercise in Early Metabolic Syndrome. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1057246
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057246