Predictive Biomarkers to Chemoradiation in Locally Advanced Rectal Cancer
Joint Authors
Conde-Muíño, Raquel
Cuadros, Marta
Zambudio, Natalia
Segura-Jiménez, Inmaculada
Cano, Carlos
Palma, Pablo
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-04
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
There has been a high local recurrence rate in rectal cancer.
Besides improvements in surgical techniques, both neoadjuvant short-course radiotherapy and long-course chemoradiation improve oncological results.
Approximately 40–60% of rectal cancer patients treated with neoadjuvant chemoradiation achieve some degree of pathologic response.
However, there is no effective method of predicting which patients will respond to neoadjuvant treatment.
Recent studies have evaluated the potential of genetic biomarkers to predict outcome in locally advanced rectal adenocarcinoma treated with neoadjuvant chemoradiation.
The articles produced by the PubMed search were reviewed for those specifically addressing a genetic profile’s ability to predict response to neoadjuvant treatment in rectal cancer.
Although tissue gene microarray profiling has led to promising data in cancer, to date, none of the identified signatures or molecular markers in locally advanced rectal cancer has been successfully validated as a diagnostic or prognostic tool applicable to routine clinical practice.
American Psychological Association (APA)
Conde-Muíño, Raquel& Cuadros, Marta& Zambudio, Natalia& Segura-Jiménez, Inmaculada& Cano, Carlos& Palma, Pablo. 2015. Predictive Biomarkers to Chemoradiation in Locally Advanced Rectal Cancer. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1057248
Modern Language Association (MLA)
Conde-Muíño, Raquel…[et al.]. Predictive Biomarkers to Chemoradiation in Locally Advanced Rectal Cancer. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1057248
American Medical Association (AMA)
Conde-Muíño, Raquel& Cuadros, Marta& Zambudio, Natalia& Segura-Jiménez, Inmaculada& Cano, Carlos& Palma, Pablo. Predictive Biomarkers to Chemoradiation in Locally Advanced Rectal Cancer. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1057248
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057248