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Coexpression Network Analysis of miRNA-142 Overexpression in Neuronal Cells
Joint Authors
Fox, Howard
Thapa, Ishwor
Bastola, Dhundy
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-11
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
MicroRNAs are small noncoding RNA molecules, which are differentially expressed in diverse biological processes and are also involved in the regulation of multiple genes.
A number of sites in the 3′ untranslated regions (UTRs) of different mRNAs allow complimentary binding for a microRNA, leading to their posttranscriptional regulation.
The miRNA-142 is one of the microRNAs overexpressed in neurons that is found to regulate SIRT1 and MAOA genes.
Differential analysis of gene expression data, which is focused on identifying up- or downregulated genes, ignores many relationships between genes affected by miRNA-142 overexpression in a cell.
Thus, we applied a correlation network model to identify the coexpressed genes and to study the impact of miRNA-142 overexpression on this network.
Combining multiple sources of knowledge is useful to infer meaningful relationships in systems biology.
We applied coexpression model on the data obtained from wild type and miR-142 overexpression neuronal cells and integrated miRNA seed sequence mapping information to identify genes greatly affected by this overexpression.
Larger differences in the enriched networks revealed that the nervous system development related genes such as TEAD2, PLEKHA6, and POGLUT1 were greatly impacted due to miRNA-142 overexpression.
American Psychological Association (APA)
Thapa, Ishwor& Fox, Howard& Bastola, Dhundy. 2015. Coexpression Network Analysis of miRNA-142 Overexpression in Neuronal Cells. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1057249
Modern Language Association (MLA)
Thapa, Ishwor…[et al.]. Coexpression Network Analysis of miRNA-142 Overexpression in Neuronal Cells. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1057249
American Medical Association (AMA)
Thapa, Ishwor& Fox, Howard& Bastola, Dhundy. Coexpression Network Analysis of miRNA-142 Overexpression in Neuronal Cells. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1057249
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057249