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Gray and White Matter Volumes and Cognitive Dysfunction in Drug-Naïve Newly Diagnosed Pediatric Epilepsy
Joint Authors
Lee, Jung Hwa
Kim, Song E.
Park, Chang-hyun
Yoo, Jeong Hyun
Lee, Hyang Woon
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-31
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Epilepsy patients often have cognitive dysfunction even at early stages of disease.
We investigated the relationship between structural findings and neuropsychological status in drug-naïve newly diagnosed pediatric epilepsy patients.
Thirty newly diagnosed pediatric epilepsy patients and 25 healthy control subjects aged 7~16 years were enrolled, who were assessed by the Korean version of the Wechsler Intelligence Scale for Children (K-WISC-III), the Stroop test, and the trail making test (TMT).
Optimized voxel-based morphometry (VBM) was performed for both Gray Matter (GM) and White Matter (WM) volumes.
Lower performance levels of verbal intelligence quotient, freedom from distractibility, and executive function were observed in epilepsy group.
Interestingly, poor performance in these cognitive subdomains was correlated with regional VBM findings involving both GM and WM volumes, but with different patterns between groups.
GM volumes revealed clear differences predominantly in the bilateral frontal regions.
These findings indicate that certain cognitive functions may be affected in the early stage of epilepsy, not related to the long-standing epilepsy or medication, but more related to the neurocognitive developmental process in this age.
Epilepsy can lead to neuroanatomical alterations in both GM and WM, which may affect cognitive functions, during early stages even before commencement of AED medication.
American Psychological Association (APA)
Lee, Jung Hwa& Kim, Song E.& Park, Chang-hyun& Yoo, Jeong Hyun& Lee, Hyang Woon. 2015. Gray and White Matter Volumes and Cognitive Dysfunction in Drug-Naïve Newly Diagnosed Pediatric Epilepsy. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1057253
Modern Language Association (MLA)
Lee, Jung Hwa…[et al.]. Gray and White Matter Volumes and Cognitive Dysfunction in Drug-Naïve Newly Diagnosed Pediatric Epilepsy. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1057253
American Medical Association (AMA)
Lee, Jung Hwa& Kim, Song E.& Park, Chang-hyun& Yoo, Jeong Hyun& Lee, Hyang Woon. Gray and White Matter Volumes and Cognitive Dysfunction in Drug-Naïve Newly Diagnosed Pediatric Epilepsy. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1057253
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057253