Association between Micronutrient Levels and Chronic Spontaneous Urticaria

Abstract EN

Previous reports have suggested a possible role for vitamin D in the etiology of chronic spontaneous urticaria (CSU); however, little information is available regarding the role of other micronutrients.

We, therefore, analyzed vitamin D, vitamin B12, and ferritin levels in CSU patients (n=282) from a preexisting database at Southampton General Hospital.

Data were compared against mean micronutrient levels of the general population of the UK, obtained from the National Diet and Nutrition Survey.

Vitamin D levels of CSU patients were found to be higher than those of the general UK population (P=0.001).

B12 levels were lower in patients with CSU (P<0.001) than in the general population.

Ferritin levels were found to be lower in male CSU patients than in the general male population (P=0.009).

This association between low B12 and iron levels and CSU might indicate a causal link, with micronutrient replacement as a potential therapeutic option.