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Transcriptome and Molecular Endocrinology Aspects of Epicardial Adipose Tissue in Cardiovascular Diseases: A Systematic Review and Meta-Analysis of Observational Studies
Joint Authors
Hossein-Nezhad, Arash
Maghbooli, Zhila
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-09
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The objective of this study was to perform a systematic review of published literature on differentially expressed genes (DEGs) in human epicardial adipose tissue (EAT) to identify molecules associated with CVDs.
A systematic literature search was conducted in PubMed, SCOPUS, and ISI Web of Science literature databases for papers published before October 2014 that addressed EAT genes and cardiovascular diseases (CVDs).
We included original papers that had performed gene expressions in EAT of patients undergoing open-heart surgery.
The Reporting Recommendations for Tumor Marker Prognostic Studies (PRIMARK) assessment tool was also used for methodological quality assessment.
From the 180 papers identified by our initial search strategy, 40 studies met the inclusion criteria and presented DEGs in EAT samples from patients with and without CVDs.
The included studies reported 42 DEGs identified through comparison of EAT-specific gene expression in patients with and without CVDs.
Among the 42 DEGs, genes involved in regulating apoptosis had higher enrichment scores.
Notably, interleukin-6 (IL-6) and tumor protein p53 (TP53) were the main hub genes in the network.
The results suggest that regulation of apoptosis in EAT is critical for CVD development.
Moreover, IL-6 and TP53 as hub genes could serve as biomarkers and therapeutic targets for CVDs.
American Psychological Association (APA)
Maghbooli, Zhila& Hossein-Nezhad, Arash. 2015. Transcriptome and Molecular Endocrinology Aspects of Epicardial Adipose Tissue in Cardiovascular Diseases: A Systematic Review and Meta-Analysis of Observational Studies. BioMed Research International،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1057269
Modern Language Association (MLA)
Maghbooli, Zhila& Hossein-Nezhad, Arash. Transcriptome and Molecular Endocrinology Aspects of Epicardial Adipose Tissue in Cardiovascular Diseases: A Systematic Review and Meta-Analysis of Observational Studies. BioMed Research International No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1057269
American Medical Association (AMA)
Maghbooli, Zhila& Hossein-Nezhad, Arash. Transcriptome and Molecular Endocrinology Aspects of Epicardial Adipose Tissue in Cardiovascular Diseases: A Systematic Review and Meta-Analysis of Observational Studies. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1057269
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057269