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Relation between Birth Weight, Growth, and Subclinical Atherosclerosis in Adulthood
Joint Authors
Gomes, Filumena Maria da Silva
Valente, Maria Helena
Escobar, Ana Maria de Ulhôa
Brentani, Alexandra Valéria Maria
Grisi, Sandra J. F. E.
Benseñor, Isabela Judith Martins
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-14
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background and Objectives.
Adverse conditions in the prenatal environment and in the first years of life are independently associated with increased risk for cardiovascular disease.
This paper aims to study the relation between birthweight, growth in the first year of life, and subclinical atherosclerosis in adults.
Methods.
88 adults aged between 20 and 31 were submitted to sociodemographic qualities, anthropometric data, blood pressure measurements, metabolic profile, and evaluation of subclinical atherosclerosis.
Results.
Birthweight <2,500 grams (g) was negatively correlated with (a) increased waist-to-hip ratio (WHR), according to regression coefficient (RC) equal to −0.323, 95% CI [−0.571, −0.075] P<0.05; (b) diastolic blood pressure (RC = −4.744, 95% CI [−9.017, −0.470] P<0.05); (c) low HDL-cholesterol (RC = −0.272, 95% CI [−0.516, −0.029] P<0.05); (d) frequency of intima-media thickness (IMT) of left carotid >75th percentile (RC = −0.242, 95% CI [−0.476, −0.008] P<0.05).
Birthweight >3,500 g was associated with (a) BMI >25.0 kg/m2, (RC = 0.317, 95% CI [0.782, 0.557] P<0.05); (b) increased waist circumference (RC = 0.284, 95% CI [0.054, 0.513] P<0.05); (c) elevated WHR (RC = 0.280, 95% CI [0.054, 0.505] P<0.05); (d) minimum subcutaneous adipose tissue (SAT) (RC = 4.354, 95% CI [0.821, 7.888] P<0.05); (e) maximum SAT (RC = 7.095, 95% CI [0.608, 13.583] P<0.05); (f) right lobe of the liver side (RC = 6.896, 95% CI [1.946, 11.847] P<0.001); (g) frequency’s right lobe of the liver >75th percentile (RC = 0.361, 95% CI [0.169, 0.552] P<0.001).
Weight gain in the first year of life was inversely correlated with (a) mean IMT of left carotid (RC = −0.046, 95% CI [−0.086, −0.006] P<0.05; (b) frequency IMT of left carotid >75th percentile (RC = −0.253, 95% CI [−0.487, −0.018] P<0.05); (c) mean IMT (RC = −0.038, 95% CI [0.073, −0.002] P<0.05); (d) the frequency of the mean IMT >75th percentile (RC = −0.241, 95% CI [−0.442, −0.041] P<0.05).
Conclusions.
Adults birthweight <2,500 g and >3,500 g and with insufficient weight gain in the first year of life have showed different metabolic phenotypes, but all of them were related to subclinical atherosclerosis.
American Psychological Association (APA)
Valente, Maria Helena& Gomes, Filumena Maria da Silva& Benseñor, Isabela Judith Martins& Brentani, Alexandra Valéria Maria& Escobar, Ana Maria de Ulhôa& Grisi, Sandra J. F. E.. 2015. Relation between Birth Weight, Growth, and Subclinical Atherosclerosis in Adulthood. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1057270
Modern Language Association (MLA)
Valente, Maria Helena…[et al.]. Relation between Birth Weight, Growth, and Subclinical Atherosclerosis in Adulthood. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1057270
American Medical Association (AMA)
Valente, Maria Helena& Gomes, Filumena Maria da Silva& Benseñor, Isabela Judith Martins& Brentani, Alexandra Valéria Maria& Escobar, Ana Maria de Ulhôa& Grisi, Sandra J. F. E.. Relation between Birth Weight, Growth, and Subclinical Atherosclerosis in Adulthood. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1057270
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057270