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microRNA Regulation of Peritoneal Cavity Homeostasis in Peritoneal Dialysis
Joint Authors
Lopez-Anton, Melisa
Bowen, Timothy
Jenkins, Robert H.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-01
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Preservation of peritoneal cavity homeostasis and peritoneal membrane function is critical for long-term peritoneal dialysis (PD) treatment.
Several microRNAs (miRNAs) have been implicated in the regulation of key molecular pathways driving peritoneal membrane alterations leading to PD failure.
miRNAs regulate the expression of the majority of protein coding genes in the human genome, thereby affecting most biochemical pathways implicated in cellular homeostasis.
In this review, we report published findings on miRNAs and PD therapy, with emphasis on evidence for changes in peritoneal miRNA expression during long-term PD treatment.
Recent work indicates that PD effluent- (PDE-) derived cells change their miRNA expression throughout the course of PD therapy, contributing to the loss of peritoneal cavity homeostasis and peritoneal membrane function.
Changes in miRNA expression profiles will alter regulation of key molecular pathways, with the potential to cause profound effects on peritoneal cavity homeostasis during PD treatment.
However, research to date has mainly adopted a literature-based miRNA-candidate methodology drawing conclusions from modest numbers of patient-derived samples.
Therefore, the study of miRNA expression during PD therapy remains a promising field of research to understand the mechanisms involved in basic peritoneal cell homeostasis and PD failure.
American Psychological Association (APA)
Lopez-Anton, Melisa& Bowen, Timothy& Jenkins, Robert H.. 2015. microRNA Regulation of Peritoneal Cavity Homeostasis in Peritoneal Dialysis. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1057283
Modern Language Association (MLA)
Lopez-Anton, Melisa…[et al.]. microRNA Regulation of Peritoneal Cavity Homeostasis in Peritoneal Dialysis. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1057283
American Medical Association (AMA)
Lopez-Anton, Melisa& Bowen, Timothy& Jenkins, Robert H.. microRNA Regulation of Peritoneal Cavity Homeostasis in Peritoneal Dialysis. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1057283
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057283