Liver Failure Impairs the Intrahepatic Elimination of Interleukin-6, Tumor Necrosis Factor-Alpha, Hepatocyte Growth Factor, and Transforming Growth Factor-Beta
Joint Authors
Pączek, Leszek
Porowski, Dawid
Wirkowska, Agnieszka
Hryniewiecka, Ewa
Wyzgał, Janusz
Pacholczyk, Marek
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-21
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The strategic location of the liver and its metabolic activity make it a key organ regulating homeostasis.
Our purpose was to examine its participation in removal of cytokines: interleukin-6 (Il-6), tumor necrosis factor-alpha (TNF-α), hepatocyte growth factor (HGF), and transforming growth factor-beta (TGF-β) from the portal circulation in human.
20 liver donors and 20 patients with end-stage liver failure were included in the study.
Their blood was collected during liver transplantation from the portal, hepatic, and peripheral vein, and the hepatic artery and cytokines’ concentrations were determined.
Using the results the mathematical model of cytokine elimination by the liver was developed.
In donors significantly lower levels of IL-6, TNF-α, HGF, and TGF-β were detected in portal blood compared to hepatic vein.
In patients with cirrhosis there were no significant differences of IL-6, TNF-α, and TGF-β levels between portal and hepatic veins.
Significantly higher level of HGF in hepatic compared to portal vein was observed.
In healthy liver elimination of the cytokines prevailed over their synthesis, as reflected by the positive values of the elimination ratios.
In the cirrhotic liver elimination ratios of Il-6, HGF, and TGF-β were negative indicating the prevalence of intrahepatic synthesis of cytokines over their removal.
American Psychological Association (APA)
Porowski, Dawid& Wirkowska, Agnieszka& Hryniewiecka, Ewa& Wyzgał, Janusz& Pacholczyk, Marek& Pączek, Leszek. 2015. Liver Failure Impairs the Intrahepatic Elimination of Interleukin-6, Tumor Necrosis Factor-Alpha, Hepatocyte Growth Factor, and Transforming Growth Factor-Beta. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1057294
Modern Language Association (MLA)
Porowski, Dawid…[et al.]. Liver Failure Impairs the Intrahepatic Elimination of Interleukin-6, Tumor Necrosis Factor-Alpha, Hepatocyte Growth Factor, and Transforming Growth Factor-Beta. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1057294
American Medical Association (AMA)
Porowski, Dawid& Wirkowska, Agnieszka& Hryniewiecka, Ewa& Wyzgał, Janusz& Pacholczyk, Marek& Pączek, Leszek. Liver Failure Impairs the Intrahepatic Elimination of Interleukin-6, Tumor Necrosis Factor-Alpha, Hepatocyte Growth Factor, and Transforming Growth Factor-Beta. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1057294
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057294