Minocycline Protection of Neomycin Induced Hearing Loss in Gerbils
Joint Authors
Richter, Claus-Peter
Robinson, A. M.
Vujanovic, Irena
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-08
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
This animal study was designed to determine if minocycline ameliorates cochlear damage is caused by intratympanic injection of the ototoxic aminoglycoside antibiotic neomycin.
Baseline auditory-evoked brainstem responses were measured in gerbils that received 40 mM intratympanic neomycin either with 0, 1.2, or 1.5 mg/kg intraperitoneal minocycline.
Four weeks later auditory-evoked brainstem responses were measured and compared to the baseline measurements.
Minocycline treatments of 1.2 mg/kg and 1.5 mg/kg resulted in significantly lower threshold increases compared to 0 mg/kg, indicating protection of hearing loss between 6 kHz and 19 kHz.
Cochleae were processed for histology and sectioned to allow quantification of the spiral ganglion neurons and histological evaluation of organ of Corti.
Significant reduction of spiral ganglion neuron density was demonstrated in animals that did not receive minocycline, indicating that those receiving minocycline demonstrated enhanced survival of spiral ganglion neurons, enhanced survival of sensory hairs cells and spiral ganglion neurons, and reduced hearing threshold elevation correlates with minocycline treatment demonstrating that neomycin induced hearing loss can be reduced by the simultaneous application of minocycline.
American Psychological Association (APA)
Robinson, A. M.& Vujanovic, Irena& Richter, Claus-Peter. 2015. Minocycline Protection of Neomycin Induced Hearing Loss in Gerbils. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1057295
Modern Language Association (MLA)
Robinson, A. M.…[et al.]. Minocycline Protection of Neomycin Induced Hearing Loss in Gerbils. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1057295
American Medical Association (AMA)
Robinson, A. M.& Vujanovic, Irena& Richter, Claus-Peter. Minocycline Protection of Neomycin Induced Hearing Loss in Gerbils. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1057295
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057295