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Application of Stochastic Automata Networks for Creation of Continuous Time Markov Chain Models of Voltage Gating of Gap Junction Channels
Joint Authors
Snipas, Mindaugas
Pranevicius, Henrikas
Pranevicius, Mindaugas
Pranevicius, Osvaldas
Paulauskas, Nerijus
Bukauskas, Feliksas F.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-01
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The primary goal of this work was to study advantages of numerical methods used for the creation of continuous time Markov chain models (CTMC) of voltage gating of gap junction (GJ) channels composed of connexin protein.
This task was accomplished by describing gating of GJs using the formalism of the stochastic automata networks (SANs), which allowed for very efficient building and storing of infinitesimal generator of the CTMC that allowed to produce matrices of the models containing a distinct block structure.
All of that allowed us to develop efficient numerical methods for a steady-state solution of CTMC models.
This allowed us to accelerate CPU time, which is necessary to solve CTMC models, ∼20 times.
American Psychological Association (APA)
Snipas, Mindaugas& Pranevicius, Henrikas& Pranevicius, Mindaugas& Pranevicius, Osvaldas& Paulauskas, Nerijus& Bukauskas, Feliksas F.. 2015. Application of Stochastic Automata Networks for Creation of Continuous Time Markov Chain Models of Voltage Gating of Gap Junction Channels. BioMed Research International،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1057302
Modern Language Association (MLA)
Snipas, Mindaugas…[et al.]. Application of Stochastic Automata Networks for Creation of Continuous Time Markov Chain Models of Voltage Gating of Gap Junction Channels. BioMed Research International No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1057302
American Medical Association (AMA)
Snipas, Mindaugas& Pranevicius, Henrikas& Pranevicius, Mindaugas& Pranevicius, Osvaldas& Paulauskas, Nerijus& Bukauskas, Feliksas F.. Application of Stochastic Automata Networks for Creation of Continuous Time Markov Chain Models of Voltage Gating of Gap Junction Channels. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1057302
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057302