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Acute and Chronic Local Inflammatory Reaction after Implantation of Different Extracellular Porcine Dermis Collagen Matrices in Rats
Joint Authors
Schlosser, Michael
Walschus, Uwe
Lucke, Silke
Hoene, Andreas
Kob, Anette
Pissarek, Jens-Wolfgang
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-14
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Two cross-linked acellular porcine dermal collagen matrices (Permacol and NRX) were implanted into rats and the acute and chronic local inflammatory tissue reactions were investigated after 7, 14, 28, and 112 days.
Both membranes were stable in vivo for up to 112 days.
All investigated immune cell populations (CD68+ macrophages, CD163+ macrophages, T lymphocytes, MHC class II positive cells, mast cells, and NK cells) were present.
Their amount decreased significantly over time compared to day 7 after implantation.
A change from an acute to a chronic inflammation and an associated shift from proinflammatory M1-like to anti-inflammatory M2-like macrophages were observed.
In the early phase there was a significant correlation of T cells to CD68+ (M1-like) macrophages, whereas in the chronic phase T lymphocytes were positively correlated with CD163+ (M2-like) macrophages.
The material NRX showed an enhanced inflammatory reaction in comparison to Permacol possibly caused by material characteristics such as a twofold higher thickness of the membrane, roughness, and water absorption capacity.
Nevertheless, a more pronounced regenerative process as, for example, indicated by nestin expression demonstrated its possible suitability for applications as wound repair material.
American Psychological Association (APA)
Lucke, Silke& Hoene, Andreas& Walschus, Uwe& Kob, Anette& Pissarek, Jens-Wolfgang& Schlosser, Michael. 2015. Acute and Chronic Local Inflammatory Reaction after Implantation of Different Extracellular Porcine Dermis Collagen Matrices in Rats. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1057305
Modern Language Association (MLA)
Lucke, Silke…[et al.]. Acute and Chronic Local Inflammatory Reaction after Implantation of Different Extracellular Porcine Dermis Collagen Matrices in Rats. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1057305
American Medical Association (AMA)
Lucke, Silke& Hoene, Andreas& Walschus, Uwe& Kob, Anette& Pissarek, Jens-Wolfgang& Schlosser, Michael. Acute and Chronic Local Inflammatory Reaction after Implantation of Different Extracellular Porcine Dermis Collagen Matrices in Rats. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1057305
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057305