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Mechanisms and Clinical Applications of Genome Instability in Multiple Myeloma
Joint Authors
Cagnetta, Antonia
Lovera, Davide
Grasso, Raffaella
Colombo, Nicoletta
Canepa, Letizia
Ballerini, Filippo
Calvio, Marino
Miglino, Maurizio
Lemoli, Roberto
Cea, Michele
Gobbi, M.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-22
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Ongoing genomic instability represents a hallmark of multiple myeloma (MM) cells, which manifests largely as whole chromosome- or translocation-based aneuploidy.
Importantly, although it supports tumorigenesis, progression and, response to treatment in MM patients, it remains one of the least understood components of malignant transformation in terms of molecular basis.
Therefore these aspects make the comprehension of genomic instability a pioneering strategy for novel therapeutic and clinical speculations to use in the management of MM patients.
Here we will review mechanisms mediating genomic instability in MM cells with an emphasis placed on pathogenic mutations affecting DNA recombination, replication and repair, telomere function and mitotic regulation of spindle attachment, centrosome function, and chromosomal segregation.
We will discuss the mechanisms by which genetic aberrations give rise to multiple pathogenic events required for myelomagenesis and conclude with a discussion of the clinical applications of these findings in MM patients.
American Psychological Association (APA)
Cagnetta, Antonia& Lovera, Davide& Grasso, Raffaella& Colombo, Nicoletta& Canepa, Letizia& Ballerini, Filippo…[et al.]. 2015. Mechanisms and Clinical Applications of Genome Instability in Multiple Myeloma. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1057329
Modern Language Association (MLA)
Cagnetta, Antonia…[et al.]. Mechanisms and Clinical Applications of Genome Instability in Multiple Myeloma. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1057329
American Medical Association (AMA)
Cagnetta, Antonia& Lovera, Davide& Grasso, Raffaella& Colombo, Nicoletta& Canepa, Letizia& Ballerini, Filippo…[et al.]. Mechanisms and Clinical Applications of Genome Instability in Multiple Myeloma. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1057329
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057329