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Management of Chemotherapy Induced Nausea and Vomiting in Patients on Multiday Cisplatin Based Combination Chemotherapy
Joint Authors
Ranganath, Praveen
Einhorn, Lawrence
Albany, Costantine
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-03
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Introduction of cisplatin based chemotherapy has revolutionized the treatment of germ cell tumors.
A common side effect of multiday cisplatin chemotherapy is severe nausea and vomiting.
Considerable progress has been made in the control of these side effects since the introduction of cisplatin based chemotherapy in the 1970s.
Germ cell tumor which is a model for a curable neoplasm has also turned into an excellent testing ground to develop effective strategies to prevent chemotherapy induced nausea and vomiting (CINV) in multiday cisplatin based regimens.
The use of combination of a 5-hydroxytryptamine (HT)3 receptor antagonist, a neurokinin-1 (NK1) antagonist, and dexamethasone has greatly improved our ability to prevent and control acute and delayed CINV.
Mechanism and pattern of CINV with multiday chemotherapy may differ from those in single day chemotherapy and therefore efficacy of antiemetic drugs as observed in single day chemotherapy may not be applicable.
There are only few randomized clinical trials with special emphasis on multiday chemotherapy.
Further studies are essential to determine the efficacy, optimal dose, and duration of the newer agents and combinations in multiday cisplatin based chemotherapy.
American Psychological Association (APA)
Ranganath, Praveen& Einhorn, Lawrence& Albany, Costantine. 2015. Management of Chemotherapy Induced Nausea and Vomiting in Patients on Multiday Cisplatin Based Combination Chemotherapy. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1057333
Modern Language Association (MLA)
Ranganath, Praveen…[et al.]. Management of Chemotherapy Induced Nausea and Vomiting in Patients on Multiday Cisplatin Based Combination Chemotherapy. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1057333
American Medical Association (AMA)
Ranganath, Praveen& Einhorn, Lawrence& Albany, Costantine. Management of Chemotherapy Induced Nausea and Vomiting in Patients on Multiday Cisplatin Based Combination Chemotherapy. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1057333
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057333