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Manifestation of Hyperandrogenism in the Continuous Light Exposure-Induced PCOS Rat Model
Joint Authors
Jia, Lina
Shen, Xueyong
Kang, Xuezhi
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Polycystic ovary syndrome (PCOS) is a complex endocrine and metabolic disorder, and its pathogenesis has yet to be completely clarified.
A fully convincing animal model has not been established for PCOS.
In earlier studies, researchers have shown that the exposure of rats to continuous light can induce PCOS; nevertheless, hyperandrogenism, a key characteristic observed in human PCOS, has not been reported previously.
In the present study, we found that (1) body weights decreased in female rats in a continuous light environment with both ovarian and uterine augmentation; (2) the estrous cycle in rats under continuous light environment was disordered, and polycystic ovary-like changes occurred, accompanied with fur loss and lethargy; and (3) serum testosterone levels in rats in a continuous light environment significantly increased.
Our data suggest that continuous light can lead to the occurrence of PCOS in female rats without the need for drugs; this is a reasonable PCOS animal model that is more consistent with the natural disease state in humans; and poor sleep habits or negligence of sleep hygiene may be an important lifestyle factor in pathogenesis of PCOS.
American Psychological Association (APA)
Kang, Xuezhi& Jia, Lina& Shen, Xueyong. 2015. Manifestation of Hyperandrogenism in the Continuous Light Exposure-Induced PCOS Rat Model. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1057335
Modern Language Association (MLA)
Kang, Xuezhi…[et al.]. Manifestation of Hyperandrogenism in the Continuous Light Exposure-Induced PCOS Rat Model. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1057335
American Medical Association (AMA)
Kang, Xuezhi& Jia, Lina& Shen, Xueyong. Manifestation of Hyperandrogenism in the Continuous Light Exposure-Induced PCOS Rat Model. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1057335
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057335