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Skin-Derived Precursor Cells Promote Angiogenesis and Stimulate Proliferation of Endogenous Neural Stem Cells after Cerebral Infarction
Joint Authors
Kong, Deling
Mao, Duo
Yao, Xinpeng
Feng, Guowei
Yang, Xiaoqing
Mao, Lina
Wang, Xiaomin
Ke, Tingyu
Che, Yongzhe
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-26
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Stroke is one of the most common diseases that caused high mortality and has become burden to the health care systems.
Stem cell transplantation has shown therapeutic effect in ameliorating ischemic damage after cerebral artery occlusion mainly due to their neurogenesis, immune regulation, or effects on the plasticity, proliferation, and survival of host cells.
Recent studies demonstrated that skin-derived precursor cells (SKPs) could promote central nervous system regeneration in spinal cord injury model or the neonatal peripheral neuron.
Here, we investigated the therapeutic potential of SKPs in a rat model of cerebral ischemia.
SKPs were isolated, expanded, and transplanted into rat cortex and striatum after transient middle cerebral artery occlusion.
Our results revealed that SKPs transplantation could improve the behavioral measures of neurological deficit.
Moreover, immunohistology confirmed that SKPs could secrete basic FGF and VEGF in the ischemic region and further markedly increase the proliferation of endogenous nestin+ and βIII-tubulin+ neural stem cells.
Furthermore, increased angiogenesis induced by SKPs was observed by vWF and α-SMA staining.
These data suggest that SKPs induced endogenous neurogenesis and angiogenesis and protected neuron from hypoxic-ischemic environment.
In conclusion, SKPs transplantation may be a promising approach in treatment of stroke.
American Psychological Association (APA)
Mao, Duo& Yao, Xinpeng& Feng, Guowei& Yang, Xiaoqing& Mao, Lina& Wang, Xiaomin…[et al.]. 2015. Skin-Derived Precursor Cells Promote Angiogenesis and Stimulate Proliferation of Endogenous Neural Stem Cells after Cerebral Infarction. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1057337
Modern Language Association (MLA)
Mao, Duo…[et al.]. Skin-Derived Precursor Cells Promote Angiogenesis and Stimulate Proliferation of Endogenous Neural Stem Cells after Cerebral Infarction. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1057337
American Medical Association (AMA)
Mao, Duo& Yao, Xinpeng& Feng, Guowei& Yang, Xiaoqing& Mao, Lina& Wang, Xiaomin…[et al.]. Skin-Derived Precursor Cells Promote Angiogenesis and Stimulate Proliferation of Endogenous Neural Stem Cells after Cerebral Infarction. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1057337
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057337