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Trichomonas vaginalis Cysteine Proteinases: Iron Response in Gene Expression and Proteolytic Activity
Joint Authors
Figueroa-Angulo, Elisa Elvira
Arroyo, Rossana
Ortega-López, Jaime
Cárdenas-Guerra, Rosa Elena
Puente-Rivera, Jonathan
Zamudio-Prieto, Olga
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-24, 24 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-18
Country of Publication
Egypt
No. of Pages
24
Main Subjects
Abstract EN
We focus on the iron response of Trichomonas vaginalis to gene family products such as the cysteine proteinases (CPs) involved in virulence properties.
In particular, we examined the effect of iron on the gene expression regulation and function of cathepsin L-like and asparaginyl endopeptidase-like CPs as virulence factors.
We addressed some important aspects about CPs genomic organization and we offer possible explanations to the fact that only few members of this large gene family are expressed at the RNA and protein levels and the way to control their proteolytic activity.
We also summarized all known iron regulations of CPs at transcriptional, posttranscriptional, and posttranslational levels along with new insights into the possible epigenetic and miRNA processes.
American Psychological Association (APA)
Arroyo, Rossana& Cárdenas-Guerra, Rosa Elena& Figueroa-Angulo, Elisa Elvira& Puente-Rivera, Jonathan& Zamudio-Prieto, Olga& Ortega-López, Jaime. 2015. Trichomonas vaginalis Cysteine Proteinases: Iron Response in Gene Expression and Proteolytic Activity. BioMed Research International،Vol. 2015, no. 2015, pp.1-24.
https://search.emarefa.net/detail/BIM-1057341
Modern Language Association (MLA)
Arroyo, Rossana…[et al.]. Trichomonas vaginalis Cysteine Proteinases: Iron Response in Gene Expression and Proteolytic Activity. BioMed Research International No. 2015 (2015), pp.1-24.
https://search.emarefa.net/detail/BIM-1057341
American Medical Association (AMA)
Arroyo, Rossana& Cárdenas-Guerra, Rosa Elena& Figueroa-Angulo, Elisa Elvira& Puente-Rivera, Jonathan& Zamudio-Prieto, Olga& Ortega-López, Jaime. Trichomonas vaginalis Cysteine Proteinases: Iron Response in Gene Expression and Proteolytic Activity. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-24.
https://search.emarefa.net/detail/BIM-1057341
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057341