Meningeal Melanomatosis: A Challenge for Timely Diagnosis
Joint Authors
Bastianello, Stefano
Diamanti, Luca
Di Stefano, Anna Luisa
Bini, Paola
Imarisio, Ilaria
Magrassi, Lorenzo
Morbini, Patrizia
Berzero, Giulia
Pedrazzoli, Paolo
Ceroni, Mauro
Marchioni, Enrico
Franciotta, D.
Farina, Lisa
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-14
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Neoplastic meningitis is a central nervous system complication that occurs in 3–5% of patients with cancer.
Although most commonly seen in patients with disseminated disease, in a small percentage of patients, it may be the initial manifestation of cancer or even primitive in origin.
In the absence of cancer history, the diagnosis of neoplastic meningitis may be challenging even for expert neurologists.
Prognosis is poor, with a median overall survival of weeks from diagnosis.
In the retrospective study herein, we described three cases of meningeal melanomatosis in patients without previous cancer history.
The patients were diagnosed with significant delay (17 to 47 weeks from symptom onset) mainly due to the deferral in performing the appropriate testing.
Even when the diagnosis was suspected, investigations by MRI, cerebrospinal fluid, or both proved at times unhelpful for confirmation.
Prognosis was dismal, with a median survival of 4 weeks after diagnosis.
Our observations are a cue to analyze the main pitfalls in the diagnosis of neoplastic meningitis in patients without cancer history and emphasize key elements that may facilitate early diagnosis.
American Psychological Association (APA)
Imarisio, Ilaria& Pedrazzoli, Paolo& Magrassi, Lorenzo& Morbini, Patrizia& Farina, Lisa& Bastianello, Stefano…[et al.]. 2015. Meningeal Melanomatosis: A Challenge for Timely Diagnosis. BioMed Research International،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1057348
Modern Language Association (MLA)
Imarisio, Ilaria…[et al.]. Meningeal Melanomatosis: A Challenge for Timely Diagnosis. BioMed Research International No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1057348
American Medical Association (AMA)
Imarisio, Ilaria& Pedrazzoli, Paolo& Magrassi, Lorenzo& Morbini, Patrizia& Farina, Lisa& Bastianello, Stefano…[et al.]. Meningeal Melanomatosis: A Challenge for Timely Diagnosis. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1057348
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057348