Effective Dose of Ramosetron for Prophylaxis of Postoperative Nausea and Vomiting in High-Risk Patients
Joint Authors
Jeong, Seongwook
Lee, Seongheon
Jeong, Sinho
Kim, Joungmin
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-14
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Postoperative nausea and vomiting (PONV) are common adverse events with an incidence of up to 80% in high-risk patients.
Ramosetron, a selective 5-HT3 receptor antagonist, is widely used to prevent PONV.
The purpose of this study was to evaluate the effective dose of ramosetron for the prevention of PONV in high-risk patients.
Methods.
Fifty-one patients were randomly allocated to 3 groups and were administered ramosetron 0.3 mg (group A), 0.45 mg (group B), or 0.6 mg (group C), at the end of their surgery.
The episodes of PONV were assessed 1, 6, 24, and 48 hours after the injection and all the adverse events were observed.
Results.
The complete response rate in the postoperative period 6–24 hours after the anesthesia was higher in group C than in group A: 93% versus 44%.
Group C’s experience score of Rhodes index was lower than group A’s: 0.81 ± 2.56 versus 3.94 ± 5.25.
No adverse drug reaction could be observed in all groups.
Conclusions.
The effective dose of ramosetron to be injected for the near-complete prophylaxis of PONV 6 to 24 hours after surgery in high-risk patients is a 0.6 mg bolus injection at the end of the surgery.
American Psychological Association (APA)
Lee, Seongheon& Jeong, Sinho& Kim, Joungmin& Jeong, Seongwook. 2015. Effective Dose of Ramosetron for Prophylaxis of Postoperative Nausea and Vomiting in High-Risk Patients. BioMed Research International،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1057358
Modern Language Association (MLA)
Lee, Seongheon…[et al.]. Effective Dose of Ramosetron for Prophylaxis of Postoperative Nausea and Vomiting in High-Risk Patients. BioMed Research International No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1057358
American Medical Association (AMA)
Lee, Seongheon& Jeong, Sinho& Kim, Joungmin& Jeong, Seongwook. Effective Dose of Ramosetron for Prophylaxis of Postoperative Nausea and Vomiting in High-Risk Patients. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1057358
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057358