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Mutations Found in embCAB, embR, and ubiA Genes of Ethambutol-Sensitive and -Resistant Mycobacterium tuberculosis Clinical Isolates from China
Joint Authors
Sun, Zhaogang
Xu, Yuhui
Huang, Hairong
Jia, Hongyan
Zhang, Zongde
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-31
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
To better understand the molecular mechanisms of Ethambutol (EMB) resistance, the mutant hot spot region of five genes (embB, embA, embC, embR, and ubiA) was amplified and sequenced in 109 EMB-resistant and 153 EMB-susceptible clinical isolates from China.
Twenty-seven EMB-susceptible isolates were found to have nonsynonym mutations, 23 of which were in embB.
The mutations occurred most frequently in embB (85.3%, 93) and were seldom in embC (2.8%, 3), embA (3.7%, 4), embR (3.7%, 4), and ubiA (8.3%, 9) in EMB-resistant isolates.
For the embB gene, 63 isolates showed mutations at embB306, 20 at embB406, nine at embB497, and five at embB354 in EMB-resistant isolates.
In addition, the particular mutants at embB406 and embB497 indicated both high levels of EMB resistance ( MICs > 5 μg/mL) and broad anti-TB drug resistance spectrums.
Our data supported the facts that embB306 could be used as a marker for EMB resistance with a sensitivity of 57.8% and a specificity of 78.8%.
American Psychological Association (APA)
Xu, Yuhui& Jia, Hongyan& Huang, Hairong& Sun, Zhaogang& Zhang, Zongde. 2015. Mutations Found in embCAB, embR, and ubiA Genes of Ethambutol-Sensitive and -Resistant Mycobacterium tuberculosis Clinical Isolates from China. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1057360
Modern Language Association (MLA)
Xu, Yuhui…[et al.]. Mutations Found in embCAB, embR, and ubiA Genes of Ethambutol-Sensitive and -Resistant Mycobacterium tuberculosis Clinical Isolates from China. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1057360
American Medical Association (AMA)
Xu, Yuhui& Jia, Hongyan& Huang, Hairong& Sun, Zhaogang& Zhang, Zongde. Mutations Found in embCAB, embR, and ubiA Genes of Ethambutol-Sensitive and -Resistant Mycobacterium tuberculosis Clinical Isolates from China. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1057360
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057360