Shengmai Injection Improved Doxorubicin-Induced Cardiomyopathy by Alleviating Myocardial Endoplasmic Reticulum Stress and Caspase-12 Dependent Apoptosis
Joint Authors
Chen, Yu
Tang, Yong
Xiang, Yin
Xie, Yu-Quan
Huang, Xiao-Hong
Zhang, Ya-Chen
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-09
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Apoptosis plays vital roles in the progression of doxorubicin-induced cardiomyopathy (DOX-CM).
Endoplasmic reticulum stress (ER stress) could induce specific apoptosis by caspase-12 dependent pathway.
Shengmai Injection (SMI), a famous Traditional Chinese Medicine, could alleviate the heart damage via inhibiting myocardial apoptosis.
However, it is unknown whether SMI can alleviate ER stress and its specific apoptosis in the setting of DOX-CM.
Objective.
To explore the effects of SMI on heart function, myocardial ER stress, and apoptosis of DOX-CM rats.
Methods.
Rats with DOX-CM were treated by SMI.
Heart function was assessed by echocardiography and brain natriuretic peptide.
Myocardial apoptosis was detected by TUNEL assay.
ER stress was assessed by detecting the expressions of GRP78 and caspase-12.
Results.
At the end of eight-week, compared to control, significant heart dysfunction happened in DOX group.
The ratio of apoptotic cardiomyocytes and the expressions of GRP78 and caspase-12 increased significantly (P<0.05).
Compared to DOX group, the apoptotic ratio and the expressions of GRP78 and caspase-12 significantly decreased in DOX + SMI group (P<0.05), accompanied with improved heart function.
Conclusion.
SMI could alleviate myocardial ER stress and caspase-12 dependent apoptosis, which subsequently helped to improve the heart function of rats with DOX-CM.
American Psychological Association (APA)
Chen, Yu& Tang, Yong& Xiang, Yin& Xie, Yu-Quan& Huang, Xiao-Hong& Zhang, Ya-Chen. 2015. Shengmai Injection Improved Doxorubicin-Induced Cardiomyopathy by Alleviating Myocardial Endoplasmic Reticulum Stress and Caspase-12 Dependent Apoptosis. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1057363
Modern Language Association (MLA)
Chen, Yu…[et al.]. Shengmai Injection Improved Doxorubicin-Induced Cardiomyopathy by Alleviating Myocardial Endoplasmic Reticulum Stress and Caspase-12 Dependent Apoptosis. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1057363
American Medical Association (AMA)
Chen, Yu& Tang, Yong& Xiang, Yin& Xie, Yu-Quan& Huang, Xiao-Hong& Zhang, Ya-Chen. Shengmai Injection Improved Doxorubicin-Induced Cardiomyopathy by Alleviating Myocardial Endoplasmic Reticulum Stress and Caspase-12 Dependent Apoptosis. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1057363
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057363