Efficacy of Olanzapine Combined Therapy for Patients Receiving Highly Emetogenic Chemotherapy Resistant to Standard Antiemetic Therapy
Joint Authors
Abe, Masakazu
Kasamatsu, Yuka
Kado, Nobuhiro
Kuji, Shiho
Tanaka, Aki
Takahashi, Nobutaka
Takekuma, Munetaka
Hirashima, Yasuyuki
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-03
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
Olanzapine is proved to be effective for chemotherapy induced nausea and vomiting (CINV).
But its efficacy in combination with standard antiemetic therapy is unknown.
The purpose of this study is to prove the preventive effect of olanzapine for the prevention of CINV caused by highly emetogenic chemotherapy when used with standard antiemetic therapy.
Method.
Gynecologic cancer patients receiving cisplatin-based chemotherapy who had grade 2 or 3 nausea in overall phase (0–120 h after chemotherapy) despite standard therapy were assigned to this study.
From the next cycles to cycles in which patients developed grade 2 or 3 nausea, they received olanzapine with standard therapy.
5 mg oral olanzapine was administered for 7 days from the day before chemotherapy.
The effectiveness of preventive administration of olanzapine was evaluated retrospectively.
The primary endpoint was nausea control rate (grade 0 or 1) with olanzapine.
Results.
Fifty patients were evaluable.
The nausea control rate with olanzapine was improved from 58% to 98% in acute phase (0–24 h after chemotherapy) and 2% to 94% in delayed phase (24–120 h after chemotherapy).
In overall phase, the nausea control rate improved from 0% to 92%, and it was statistically significant (P<0.001).
Conclusion.
Preventive use of olanzapine combined with standard antiemetic therapy showed improvement in control of refractory nausea.
American Psychological Association (APA)
Abe, Masakazu& Kasamatsu, Yuka& Kado, Nobuhiro& Kuji, Shiho& Tanaka, Aki& Takahashi, Nobutaka…[et al.]. 2015. Efficacy of Olanzapine Combined Therapy for Patients Receiving Highly Emetogenic Chemotherapy Resistant to Standard Antiemetic Therapy. BioMed Research International،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1057372
Modern Language Association (MLA)
Abe, Masakazu…[et al.]. Efficacy of Olanzapine Combined Therapy for Patients Receiving Highly Emetogenic Chemotherapy Resistant to Standard Antiemetic Therapy. BioMed Research International No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1057372
American Medical Association (AMA)
Abe, Masakazu& Kasamatsu, Yuka& Kado, Nobuhiro& Kuji, Shiho& Tanaka, Aki& Takahashi, Nobutaka…[et al.]. Efficacy of Olanzapine Combined Therapy for Patients Receiving Highly Emetogenic Chemotherapy Resistant to Standard Antiemetic Therapy. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1057372
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057372