Is Vitamin D Deficiency Related to Accumulation of Advanced Glycation End Products, Markers of Inflammation, and Oxidative Stress in Diabetic Subjects?
Joint Authors
Sebekova, Katerina
Stürmer, M.
Fazeli, G.
Bahner, U.
Stäb, F.
Heidland, A.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-27
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Objectives.
In diabetes accumulated advanced glycation end products (AGEs) are involved in the striking cardiovascular morbidity/mortality.
We asked whether a hypovitaminosis D associates with an increased formation and toxicity of AGEs in diabetes.
Methods.
In 276 diabetics (160 M/116 F, age: 65.0±13.4; 43 type 1,T1DM, and 233 type 2 patients, T2DM) and 121 nondiabetic controls (60 M/61 F; age: 58.6±15.5 years) routine biochemistry, levels of 25-hydroxyvitamin D3 (25-(OH)D), skin autofluorescence (SAF), plasma AGE-associated fluorescence (AGE-FL), Nε-(carboxymethyl)lysine (CML), soluble receptor for AGEs (sRAGE), soluble vascular adhesion protein-1 (sVAP-1), high sensitive C-reactive protein (hs-CRP), and renal function (eGFR) were determined.
Results.
In the diabetics SAF and AGE-Fl were higher than those of the controls and correlated with age, duration of diabetes, and degree of renal impairment.
In T2DM patients but not in T1DM the age-dependent rise of SAF directly correlated with hs-CRP and sVAP-1.
25-(OH)D levels in diabetics and nondiabetics were lowered to a similar degree averaging 22.5 ng/mL.
No relationship between 25-(OH)D and studied markers except for sVAP-1 was observed in the diabetics.
Conclusion.
In diabetics hypovitaminosis D does not augment accumulation of AGEs and studied markers of microinflammation and oxidative stress except for sVAP-1.
American Psychological Association (APA)
Sebekova, Katerina& Stürmer, M.& Fazeli, G.& Bahner, U.& Stäb, F.& Heidland, A.. 2015. Is Vitamin D Deficiency Related to Accumulation of Advanced Glycation End Products, Markers of Inflammation, and Oxidative Stress in Diabetic Subjects?. BioMed Research International،Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1057374
Modern Language Association (MLA)
Sebekova, Katerina…[et al.]. Is Vitamin D Deficiency Related to Accumulation of Advanced Glycation End Products, Markers of Inflammation, and Oxidative Stress in Diabetic Subjects?. BioMed Research International No. 2015 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1057374
American Medical Association (AMA)
Sebekova, Katerina& Stürmer, M.& Fazeli, G.& Bahner, U.& Stäb, F.& Heidland, A.. Is Vitamin D Deficiency Related to Accumulation of Advanced Glycation End Products, Markers of Inflammation, and Oxidative Stress in Diabetic Subjects?. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1057374
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057374