Myofibroblast Expression in Skin Wounds Is Enhanced by Collagen III Suppression
Joint Authors
al-Qattan, Mohammad M.
Shier, Medhat K.
Abd-Al Wahed, Mervat M.
Arafah, Maha M.
Hawary, Khalid
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-19
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Generally speaking, the excessive expression of myofibroblasts is associated with excessive collagen production.
One exception is seen in patients and animal models of Ehlers-Danlos syndrome type IV in which the COL3A1 gene mutation results in reduced collagen III but with concurrent increased myofibroblast expression.
This paradox has not been examined with the use of external drugs/modalities to prevent hypertrophic scars.
In this paper, we injected the rabbit ear wound model of hypertrophic scarring with two doses of a protein called nAG, which is known to reduce collagen expression and to suppress hypertrophic scarring in that animal model.
The higher nAG dose was associated with significantly less collagen III expression and concurrent higher degree of myofibroblast expression.
We concluded that collagen III content of the extracellular matrix may have a direct or an indirect effect on myofibroblast differentiation.
However, further research is required to investigate the pathogenesis of this paradoxical phenomenon.
American Psychological Association (APA)
al-Qattan, Mohammad M.& Abd-Al Wahed, Mervat M.& Hawary, Khalid& Arafah, Maha M.& Shier, Medhat K.. 2015. Myofibroblast Expression in Skin Wounds Is Enhanced by Collagen III Suppression. BioMed Research International،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1057379
Modern Language Association (MLA)
al-Qattan, Mohammad M.…[et al.]. Myofibroblast Expression in Skin Wounds Is Enhanced by Collagen III Suppression. BioMed Research International No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1057379
American Medical Association (AMA)
al-Qattan, Mohammad M.& Abd-Al Wahed, Mervat M.& Hawary, Khalid& Arafah, Maha M.& Shier, Medhat K.. Myofibroblast Expression in Skin Wounds Is Enhanced by Collagen III Suppression. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1057379
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057379