cspA Influences Biofilm Formation and Drug Resistance in Pathogenic Fungus Aspergillus fumigatus
Joint Authors
Fan, Zhongqi
Li, Zhe
Xu, Zongge
Li, Hongyan
Li, Lixiang
Ning, Cong
Ma, Lin
Xie, Xiangli
Wang, Guangyi
Yu, Huimei
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The microbial cell wall plays a crucial role in biofilm formation and drug resistance.
cspA encodes a repeat-rich glycophosphatidylinositol-anchored cell wall protein in the pathogenic fungus Aspergillus fumigatus.
To determine whether cspA has a significant impact on biofilm development and sensitivity to antifungal drugs in A.
fumigatus, a ΔcspA mutant was constructed by targeted gene disruption, and we then reconstituted the mutant to wild type by homologous recombination of a functional cspA gene.
Deletion of cspA resulted in a rougher conidial surface, reduced biofilm formation, decreased resistance to antifungal agents, and increased internalization by A549 human lung epithelial cells, suggesting that cspA not only participates in maintaining the integrity of the cell wall, but also affects biofilm establishment, drug response, and invasiveness of A.
fumigatus.
American Psychological Association (APA)
Fan, Zhongqi& Li, Zhe& Xu, Zongge& Li, Hongyan& Li, Lixiang& Ning, Cong…[et al.]. 2015. cspA Influences Biofilm Formation and Drug Resistance in Pathogenic Fungus Aspergillus fumigatus. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1057387
Modern Language Association (MLA)
Fan, Zhongqi…[et al.]. cspA Influences Biofilm Formation and Drug Resistance in Pathogenic Fungus Aspergillus fumigatus. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1057387
American Medical Association (AMA)
Fan, Zhongqi& Li, Zhe& Xu, Zongge& Li, Hongyan& Li, Lixiang& Ning, Cong…[et al.]. cspA Influences Biofilm Formation and Drug Resistance in Pathogenic Fungus Aspergillus fumigatus. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1057387
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057387