Improved Diagnostic Multimodal Biomarkers for Alzheimer’s Disease and Mild Cognitive Impairment
Joint Authors
Martinez-Torteya, Antonio
Treviño, Victor
Tamez-Peña, José
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-28
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The early diagnosis of Alzheimer’s disease (AD) and mild cognitive impairment (MCI) is very important for treatment research and patient care purposes.
Few biomarkers are currently considered in clinical settings, and their use is still optional.
The objective of this work was to determine whether multimodal and nonpreviously AD associated features could improve the classification accuracy between AD, MCI, and healthy controls, which may impact future AD biomarkers.
For this, Alzheimer’s Disease Neuroimaging Initiative database was mined for case-control candidates.
At least 652 baseline features extracted from MRI and PET analyses, biological samples, and clinical data up to February 2014 were used.
A feature selection methodology that includes a genetic algorithm search coupled to a logistic regression classifier and forward and backward selection strategies was used to explore combinations of features.
This generated diagnostic models with sizes ranging from 3 to 8, including well documented AD biomarkers, as well as unexplored image, biochemical, and clinical features.
Accuracies of 0.85, 0.79, and 0.80 were achieved for HC-AD, HC-MCI, and MCI-AD classifications, respectively, when evaluated using a blind test set.
In conclusion, a set of features provided additional and independent information to well-established AD biomarkers, aiding in the classification of MCI and AD.
American Psychological Association (APA)
Martinez-Torteya, Antonio& Treviño, Victor& Tamez-Peña, José. 2015. Improved Diagnostic Multimodal Biomarkers for Alzheimer’s Disease and Mild Cognitive Impairment. BioMed Research International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1057394
Modern Language Association (MLA)
Martinez-Torteya, Antonio…[et al.]. Improved Diagnostic Multimodal Biomarkers for Alzheimer’s Disease and Mild Cognitive Impairment. BioMed Research International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1057394
American Medical Association (AMA)
Martinez-Torteya, Antonio& Treviño, Victor& Tamez-Peña, José. Improved Diagnostic Multimodal Biomarkers for Alzheimer’s Disease and Mild Cognitive Impairment. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1057394
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057394