Amylose-Based Cationic Star Polymers for siRNA Delivery
Joint Authors
Nishimura, Tomoki
Umezaki, Kaori
Mukai, Sada-atsu
Sawada, Shin-ichi
Akiyoshi, Kazunari
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-11
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
A new siRNA delivery system using a cationic glyco-star polymer is described.
Spermine-modified 8-arm amylose star polymer (with a degree of polymerization of approximately 60 per arm) was synthesized by chemoenzymatic methods.
The cationic star polymer effectively bound to siRNA and formed spherical complexes with an average hydrodynamic diameter of 230 nm.
The cationic 8-arm star polymer complexes showed superior cellular uptake characteristics and higher gene silencing effects than a cationic 1-arm polymer.
These results suggest that amylose-based star polymers are a promising nanoplatform for glycobiomaterials.
American Psychological Association (APA)
Nishimura, Tomoki& Umezaki, Kaori& Mukai, Sada-atsu& Sawada, Shin-ichi& Akiyoshi, Kazunari. 2015. Amylose-Based Cationic Star Polymers for siRNA Delivery. BioMed Research International،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1057401
Modern Language Association (MLA)
Nishimura, Tomoki…[et al.]. Amylose-Based Cationic Star Polymers for siRNA Delivery. BioMed Research International No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1057401
American Medical Association (AMA)
Nishimura, Tomoki& Umezaki, Kaori& Mukai, Sada-atsu& Sawada, Shin-ichi& Akiyoshi, Kazunari. Amylose-Based Cationic Star Polymers for siRNA Delivery. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1057401
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057401
