![](/images/graphics-bg.png)
Five-Year Follow-Up of Concomitant Accelerated Hypofractionated Radiation in Advanced Squamous Cell Carcinoma of the Buccal Mucosa: A Retrospective Cohort Study
Joint Authors
Bhatti, Abu Bakar Hafeez
Iqbal, Hassan
Jamshed, Arif
Jamshed, Sarah
Irfan, Muhammad
Hameed, Natasha
Illyas, Adeel
Hussain, Raza
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-14
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
In resource limited settings, induction chemotherapy with Gemcitabine and Cisplatinum and concurrent hypofractionated chemoradiation for locally advanced carcinoma of buccal mucosa (BMSCC) are a cost effective option but remain under reported.
The objective of this study was to report long term survival outcome after concurrent hypofractionated radiotherapy in locally advanced BMSCC.
Between February 2005 and 2009, 63 patients received treatment.
Induction chemotherapy (IC) regimen consisted of two drugs: Gemcitabine and Cisplatin.
All patients received 55 Gy of radiation in 20 fractions with concurrent single agent Cisplatin (75 mg/m2).
Five-year overall survival (OS), disease-free survival (DFS), and progression-free survival (PFS) were determined.
Based on AJCC staging, 7 (11%) patients were stage III, 31 (49%) stage IV a, and 25 (40%) stage IVb at presentation.
After IC, 8 (18%) patients had complete radiological response, 33 (73%) had partial response, and 4 (9%) had stable disease.
After concurrent hypofractionated chemoradiation, thirty-nine (62%) patients were complete responders and 24 (38%) had stable disease.
With a minimum follow-up of 60 months, 5-year OS, DFS, and PFS were 30%, 49%, and 30%, respectively.
In locally advanced buccal mucosa squamous cell carcinoma, concurrent hypofractionated chemoradiation results in acceptable survival and regimen related toxicity.
American Psychological Association (APA)
Iqbal, Hassan& Jamshed, Arif& Bhatti, Abu Bakar Hafeez& Hussain, Raza& Jamshed, Sarah& Irfan, Muhammad…[et al.]. 2015. Five-Year Follow-Up of Concomitant Accelerated Hypofractionated Radiation in Advanced Squamous Cell Carcinoma of the Buccal Mucosa: A Retrospective Cohort Study. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1057404
Modern Language Association (MLA)
Iqbal, Hassan…[et al.]. Five-Year Follow-Up of Concomitant Accelerated Hypofractionated Radiation in Advanced Squamous Cell Carcinoma of the Buccal Mucosa: A Retrospective Cohort Study. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1057404
American Medical Association (AMA)
Iqbal, Hassan& Jamshed, Arif& Bhatti, Abu Bakar Hafeez& Hussain, Raza& Jamshed, Sarah& Irfan, Muhammad…[et al.]. Five-Year Follow-Up of Concomitant Accelerated Hypofractionated Radiation in Advanced Squamous Cell Carcinoma of the Buccal Mucosa: A Retrospective Cohort Study. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1057404
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057404