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Insights in Behavior of Variably Formulated Alginate-Based Microcapsules for Cell Transplantation
Joint Authors
Montanucci, Pia
Terenzi, Silvia
Santi, Claudio
Pennoni, Ilaria
Bini, Vittorio
Pescara, Teresa
Basta, Giuseppe
Calafiore, Riccardo
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-20
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Alginate-based microencapsulation of live cells may offer the opportunity to treat chronic and degenerative disorders.
So far, a thorough assessment of physical-chemical behavior of alginate-based microbeads remains cloudy.
A disputed issue is which divalent cation to choose for a high performing alginate gelling process.
Having selected, in our system, high mannuronic (M) enriched alginates, we studied different gelling cations and their combinations to determine their eventual influence on physical-chemical properties of the final microcapsules preparation, in vitro and in vivo.
We have shown that used of ultrapure alginate allows for high biocompatibility of the formed microcapsules, regardless of gelation agents, while use of different gelling cations is associated with corresponding variable effects on the capsules’ basic architecture, as originally reported in this work.
However, only the final application which the capsules are destined to will ultimately guide the selection of the ideal, specific gelling divalent cations, since in principle there are no capsules that are better than others.
American Psychological Association (APA)
Montanucci, Pia& Terenzi, Silvia& Santi, Claudio& Pennoni, Ilaria& Bini, Vittorio& Pescara, Teresa…[et al.]. 2015. Insights in Behavior of Variably Formulated Alginate-Based Microcapsules for Cell Transplantation. BioMed Research International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1057415
Modern Language Association (MLA)
Montanucci, Pia…[et al.]. Insights in Behavior of Variably Formulated Alginate-Based Microcapsules for Cell Transplantation. BioMed Research International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1057415
American Medical Association (AMA)
Montanucci, Pia& Terenzi, Silvia& Santi, Claudio& Pennoni, Ilaria& Bini, Vittorio& Pescara, Teresa…[et al.]. Insights in Behavior of Variably Formulated Alginate-Based Microcapsules for Cell Transplantation. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1057415
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057415