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An Expedient Synthesis, Acetylcholinesterase Inhibitory Activity, and Molecular Modeling Study of Highly Functionalized Hexahydro-1,6-naphthyridines
Joint Authors
Ashraf Ali, Mohamed
Suresh Kumar, Raju
Almansour, Abdulrahman I.
Arumugam, Natarajan
Basiri, Alireza
Kia, Yalda
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-29
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
A series of hexahydro-1,6-naphthyridines were synthesized in good yields by the reaction of 3,5-bis[(E)-arylmethylidene]tetrahydro-4(1H)-pyridinones with cyanoacetamide in the presence of sodium ethoxide under simple mixing at ambient temperature for 6–10 minutes and were assayed for their acetylcholinesterase (AChE) inhibitory activity using colorimetric Ellman’s method.
Compound 4e with methoxy substituent at ortho-position of the phenyl rings displayed the maximum inhibitory activity with IC50 value of 2.12 μM.
Molecular modeling simulation of 4e was performed using three-dimensional structure of Torpedo californica AChE (TcAChE) enzyme to disclose binding interaction and orientation of this molecule into the active site gorge of the receptor.
American Psychological Association (APA)
Almansour, Abdulrahman I.& Suresh Kumar, Raju& Arumugam, Natarajan& Basiri, Alireza& Kia, Yalda& Ashraf Ali, Mohamed. 2015. An Expedient Synthesis, Acetylcholinesterase Inhibitory Activity, and Molecular Modeling Study of Highly Functionalized Hexahydro-1,6-naphthyridines. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1057417
Modern Language Association (MLA)
Almansour, Abdulrahman I.…[et al.]. An Expedient Synthesis, Acetylcholinesterase Inhibitory Activity, and Molecular Modeling Study of Highly Functionalized Hexahydro-1,6-naphthyridines. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1057417
American Medical Association (AMA)
Almansour, Abdulrahman I.& Suresh Kumar, Raju& Arumugam, Natarajan& Basiri, Alireza& Kia, Yalda& Ashraf Ali, Mohamed. An Expedient Synthesis, Acetylcholinesterase Inhibitory Activity, and Molecular Modeling Study of Highly Functionalized Hexahydro-1,6-naphthyridines. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1057417
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057417