Basic Fibroblast Growth Factor Ameliorates Endothelial Dysfunction in Radiation-Induced Bladder Injury
Joint Authors
Zhang, Shiwei
Qiu, Xuefeng
Zhang, Yanting
Fu, Kai
Zhao, Xiaozhi
Wu, Jinhui
Hu, Yiqiao
Zhu, Weiming
Guo, Hongqian
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-13
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
This study was designed to explore the effect of basic fibroblast growth factor (bFGF) on radiation-induced endothelial dysfunction and histological changes in the urinary bladder.
bFGF was administrated to human umbilical vein cells (HUVEC) or urinary bladder immediately after radiation.
Reduced expression of thrombomodulin (TM) was indicated in the HUVEC and urinary bladder after treatment with radiation.
Decreased apoptosis was observed in HUVEC treated with bFGF.
Administration of bFGF increased the expression of TM in HUVEC medium, as well as in the urinary bladder at the early and delayed phases of radiation-induced bladder injury (RIBI).
At the early phase, injection of bFGF increased the thickness of urothelium and reduced inflammation within the urinary bladder.
At the delayed phase, bFGF was effective in reducing fibrosis within the urinary bladder.
Our results indicate that endothelial dysfunction is a prominent feature of RIBI.
Administration of bFGF can ameliorate radiation-induced endothelial dysfunction in urinary bladder and preserve bladder histology at early and delayed phases of RIBI.
American Psychological Association (APA)
Zhang, Shiwei& Qiu, Xuefeng& Zhang, Yanting& Fu, Kai& Zhao, Xiaozhi& Wu, Jinhui…[et al.]. 2015. Basic Fibroblast Growth Factor Ameliorates Endothelial Dysfunction in Radiation-Induced Bladder Injury. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1057420
Modern Language Association (MLA)
Zhang, Shiwei…[et al.]. Basic Fibroblast Growth Factor Ameliorates Endothelial Dysfunction in Radiation-Induced Bladder Injury. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1057420
American Medical Association (AMA)
Zhang, Shiwei& Qiu, Xuefeng& Zhang, Yanting& Fu, Kai& Zhao, Xiaozhi& Wu, Jinhui…[et al.]. Basic Fibroblast Growth Factor Ameliorates Endothelial Dysfunction in Radiation-Induced Bladder Injury. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1057420
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057420