A Survival Association Study of 102 Polymorphisms Previously Associated with Survival Outcomes in Colorectal Cancer
Joint Authors
Xu, Wei
Savas, Sevtap
Xu, Jingxiong
Werdyani, Salem
Shestopaloff, Konstantin
Dicks, Elizabeth
Green, Jane
Parfrey, Patrick
Green, Roger
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-12
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Several published studies identified associations of a number of polymorphisms with a variety of survival outcomes in colorectal cancer.
In this study, we aimed to explore 102 previously reported common genetic polymorphisms and their associations with overall survival (OS) and disease-free survival (DFS) in a colorectal cancer patient cohort from Newfoundland n=505.
Genotypes were obtained using a genomewide SNP genotyping platform.
For each polymorphism, the best possible genetic model was estimated for both overall survival and disease-free survival using a previously published approach.
These SNPs were then analyzed under their genetic models by Cox regression method.
Correction for multiple comparisons was performed by the False Discovery Rate (FDR) method.
Univariate analysis results showed that RRM1-rs12806698, IFNGR1-rs1327474, DDX20-rs197412, and PTGS2-rs5275 polymorphisms were nominally associated with OS or DFS p<0.01.
In stage-adjusted analysis, the nominal associations of DDX20-rs197412, PTGS2-rs5275, and HSPA5-rs391957 with DFS were detected.
However, after FDR correction none of these polymorphisms remained significantly associated with the survival outcomes.
We conclude that polymorphisms investigated in this study are not associated with OS or DFS in our colorectal cancer patient cohort.
American Psychological Association (APA)
Savas, Sevtap& Xu, Jingxiong& Werdyani, Salem& Shestopaloff, Konstantin& Dicks, Elizabeth& Green, Jane…[et al.]. 2015. A Survival Association Study of 102 Polymorphisms Previously Associated with Survival Outcomes in Colorectal Cancer. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1057427
Modern Language Association (MLA)
Savas, Sevtap…[et al.]. A Survival Association Study of 102 Polymorphisms Previously Associated with Survival Outcomes in Colorectal Cancer. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1057427
American Medical Association (AMA)
Savas, Sevtap& Xu, Jingxiong& Werdyani, Salem& Shestopaloff, Konstantin& Dicks, Elizabeth& Green, Jane…[et al.]. A Survival Association Study of 102 Polymorphisms Previously Associated with Survival Outcomes in Colorectal Cancer. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1057427
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057427